推荐产品
产品名称
二苯基硼酸-2-氨基乙酯, A cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release.
质量水平
方案
≥97% (titration)
表单
crystalline solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
颜色
white
溶解性
DMSO: 20 mg/mL
95% ethanol: 25 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
B(OCCN)(c2ccccc2)c1ccccc1
InChI
1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
InChI key
BLZVCIGGICSWIG-UHFFFAOYSA-N
一般描述
Ins（1,4,5）P3诱导Ca2+释放的细胞渗透性调节剂。可抑制大鼠小脑微粒体中Ins（1,4,5）P3诱导的Ca2+释放（IC50 = 42 µM），且不会影响[3H]-Ins（1,4,5）P3 与其受体的结合。其对Ca2+从对精氨酸敏感的Ca2+库（由大鼠腿部骨骼肌和心脏中制备得到）中释放没有影响。可抑制子宫收缩剂诱导的自发性收缩和相位收缩。也有报道其可抑制血管紧张素Ⅱ诱导的主动脉收缩。
Ins（1,4,5）P3诱导Ca2+释放的细胞渗透性调节剂。可抑制大鼠小脑微粒体中Ins（1,4,5）P3诱导的Ca2+释放（IC50 = 42 µM），且不会影响[3H]-Ins（1,4,5）P3 与其受体的结合。在肝细胞中，2-APB可通过一种可能涉及其与通道蛋白或相关调节蛋白结合的机制，来抑制Ca2+库通道。其对Ca2+从对精氨酸敏感的Ca2+库（由大鼠腿部骨骼肌和心脏中制备得到）中释放没有影响。
生化/生理作用
主要靶标
Ins（1,4,5）P3诱导的Ca2+释放
Ins（1,4,5）P3诱导的Ca2+释放
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
靶标IC50：42 µM，抑制Ins（1,4,5）P3诱导的大鼠小脑微粒体制剂中Ca2+的释放
包装
用惰性气体包装
警告
毒性：标准处理（A）
重悬
溶解后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存2个月。
其他说明
Brooke, R. T., et al. 2004.Lab. Invest.84, 29.
Gregory, R.B., et al. 2001.Biochem.J.354, 285.
Ma, H.T., et al. 2001.J. Biol. Chem.276, 18888.
Ascher-Landsberg, S., et al. 1999.Biochem.Biophys.Res. Commun.264, 979.
Maruyama, T., et al. 1997.J. Biochem.122, 498.
Gregory, R.B., et al. 2001.Biochem.J.354, 285.
Ma, H.T., et al. 2001.J. Biol. Chem.276, 18888.
Ascher-Landsberg, S., et al. 1999.Biochem.Biophys.Res. Commun.264, 979.
Maruyama, T., et al. 1997.J. Biochem.122, 498.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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