产品名称
抗-Wnt3A抗体, Upstate®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, mouse, rat
manufacturer/tradename
Upstate®
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... WNT3A(89780)
Analysis Note
通过免疫印迹对大鼠脑裂解液进行了常规评估
Application
抗Wnt3A抗体是针对Wnt3A的抗体，用于WB，IH（P）。
研究子类别
发育信号转导
发育信号转导
研究类别
信号传导
信号传导
Biochem/physiol Actions
可识别Wnt3A
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
Wnt家族由参与细胞发育，去向决定，器官发生和肿瘤发生的配体组成。Wnt信号的信息已从果蝇中无翅（wg）信号的遗传分析中推断出来。当Wnt与其受体，卷曲蛋白（Fz）跨膜受体家族的成员以及脂蛋白受体–相关蛋白5和6（LRP-5/6）相互作用时，Wnt信号级联反应在细胞膜上启动。这种相互作用将信号中继到细胞内部，在那里disheveled（dsh）被带到膜上并被磷酸化/激活。Dsh促进GSK3激酶活性的失活，从而防止β-连环蛋白的磷酸化并使其积累，因为它避免了泛素化和随后的蛋白体降解。稳定的β-连环蛋白在细胞质中积累，在那里它与淋巴增强因子/T细胞因子（LEF/TCF）相互作用并转移到细胞核中。这导致TCF反应性基因的激活，该基因被认为在发育和癌症中起关键作用。该途径的负调节剂可能包括axin和肿瘤抑制因子APC。
~40 kDa
Immunogen
表位：中心
针对人、小鼠和大鼠Wnt3a中央区域的合成KLH偶联肽。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
亲和纯化
在含有PBS和0.05%叠氮化钠的储存缓冲液中的亲和纯化兔多克隆。
Preparation Note
自收到之日起在2-8°C可稳定保存1年。
处理建议：收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。
处理建议：收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Yuanyuan Geng et al.
Molecular medicine reports, 15(4), 1601-1606 (2017-03-06)
Numerous patients with anorectal malformations (ARMs) continue to experience fecal incontinence and constipation following surgical procedures. One of the most important factors that influences defecation is the striated muscle complex (SMC). Wnt signaling regulates the expression of myogenic regulatory factors
Ruoxi Liao et al.
Nephrology (Carlton, Vic.), 25(3), 264-272 (2019-11-12)
Vascular calcification (VC) is a common complication in chronic kidney disease (CKD) and has been shown to be associated with increased cardiovascular events and mortality. This study was to explore the role of Wnt-signaling pathway in CKD VC, and the
Kristina Rydell-Törmänen et al.
Physiological reports, 4(5) (2016-03-22)
Idiopathic pulmonary fibrosis (IPF), an insidious disease with grave prognosis, is characterized by heterogeneous fibrosis with densely fibrotic areas surrounded by nonfibrotic normal-looking tissue, believed to reflect a temporal development. The etiology is incompletely elucidated, but aberrant wound healing is
Susumu Wada et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 37(7), 1628-1637 (2019-04-13)
Mechanical stress has an important effect on tendon-to-bone healing. The purpose of the present study was to compare tendon-to-bone healing in animals exposed to either tendon unloading (botulinum toxin injection) or excessive loading (treadmill running) in a murine rotator cuff
WNT3A gene expression is associated with isolated Hirschsprung disease polymorphism and disease status.
Chen, D; Mi, J; Liu, X; Zhang, J; Wang, W; Gao, H
International Journal of Clinical and Experimental Pathology null
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