09-078
抗-EHMT1/GLP1抗体
Upstate®, from rabbit
别名:
G9a like protein, H3-K9-HMTase, Histone H3-K9 methyltransferase, Histone-lysine N-methyltransferase, H3 lysine-9 specific, EC 2.1.1.43, euchromatic histone methyltransferase 1, euchromatic histone-lysine N-methyltransferase 1, Eu-HMTase1, FLJ12879 1, FP1
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所有图片(1)
About This Item
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41
生物来源
rabbit
质量水平
抗体形式
affinity purified immunoglobulin
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
human
制造商/商品名称
Upstate®
技术
western blot: suitable
同位素/亚型
IgG
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... EHMT1(79813)
一般描述
G9a样蛋白1（GLP1），也称常染色质组蛋白赖氨酸N-甲基转移酶1（EMHT1），是一种组蛋白甲基转移酶，可甲基化组蛋白H3的Lys9。H3Lys9甲基化是表观遗传转录抑制的标志。EMHT1/GLP1通过不同的DNA结合蛋白（如E2F6、MGA、MAX和/或DP1）靶向组蛋白H3。在G0期，它有助于Myc-和E2F-应答基因的沉默，表明在细胞周期的G0/G1过渡中发挥作用。 EMHT1/GLP1在DNA损伤时发生磷酸化，原因可能是ATM或ATR。 EHMT1的缺陷会导致严重的智力迟钝、张力低下和癫痫发作。
特异性
识别EMHT1/GLP1
免疫原
KLH偶联合成肽（KHTQDSARVNPQDGTNTLTR(C)），对应于人EMHT1/GLP1的氨基酸40-59。
表位：氨基酸40-59
应用
抗-EHMT1/GLP1抗体（兔多克隆抗体）经验证可用于在WB中检测EHMT1/GLP1，也称H3-K9-HMTase 5、组蛋白H3-K9甲基转移酶5。
研究子类别
染色质生物学
组蛋白
染色质生物学
组蛋白
研究类别
表观遗传学&核功能
表观遗传学&核功能
质量
已通过免疫印迹进行常规评估。
目标描述
160 kda
外形
免疫亲和纯化
免疫亲和纯化兔IgG溶于PBS，含0.1%叠氮化钠、30％甘油
储存及稳定性
自收到之日起，在 -20°C条件下可稳定保存1年。
处理建议：收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。分装到微量离心管中，并储存于-20°C。避免反复冻融循环，以免损坏IgG和影响产品性能
处理建议：收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。分装到微量离心管中，并储存于-20°C。避免反复冻融循环，以免损坏IgG和影响产品性能
其他说明
浓度：请参考批次特异性浓缩物的检验报告。
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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WGK
WGK 2
Dan Levy et al.
Nature immunology, 12(1), 29-36 (2010-12-07)
Signaling via the methylation of lysine residues in proteins has been linked to diverse biological and disease processes, yet the catalytic activity and substrate specificity of many human protein lysine methyltransferases (PKMTs) are unknown. We screened over 40 candidate PKMTs
Rui Wang et al.
Journal of the American Chemical Society, 135(3), 1048-1056 (2012-12-19)
Protein methyltransferases (PMTs) have emerged as important epigenetic regulators in myriad biological processes in both normal physiology and disease conditions. However, elucidating PMT-regulated epigenetic processes has been hampered by ambiguous knowledge about in vivo activities of individual PMTs particularly because
Coralie Poulard et al.
EMBO reports, 18(8), 1442-1459 (2017-06-16)
Like many transcription regulators, histone methyltransferases G9a and G9a-like protein (GLP) can act gene-specifically as coregulators, but mechanisms controlling this specificity are mostly unknown. We show that adjacent post-translational methylation and phosphorylation regulate binding of G9a and GLP to heterochromatin
Coralie Poulard et al.
Cell death & disease, 9(10), 1038-1038 (2018-10-12)
Synthetic glucocorticoids (GCs) are used to treat lymphoid cancers, but many patients develop resistance to treatment, especially to GC. By identifying genes that influence sensitivity to GC-induced cell death, we found that histone methyltransferases G9a and G9a-like protein (GLP), two
Xiaopeng Lu et al.
Nucleic acids research, 47(21), 10977-10993 (2019-10-16)
The binding of p53-binding protein 1 (53BP1) to damaged chromatin is a critical event in non-homologous DNA end joining (NHEJ)-mediated DNA damage repair. Although several molecular pathways explaining how 53BP1 binds damaged chromatin have been described, the precise underlying mechanisms
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