产品名称
Anti-phospho-Src (Tyr418) 抗体, Upstate®, from rabbit
biological source
rabbit
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
chicken, human, mouse
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
phosphorylation (pTyr418)
Quality Level
Gene Information
human ... SRC(6714)
Application
Research Category
Signaling
Signaling
Anti-phospho-Src (Tyr418) Antibody detects level of phospho-Src (Tyr418) & has been published & validated for use in IC, IH & WB.
Immunoblot Analysis: 1:1000 dilutions of this lot detected phospho-Src (Tyr418) in RIPA lysate of Src transfected CEF cells.
Research Sub Category
Cytoskeletal Signaling
Cytoskeletal Signaling
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Physical form
ImmunoAffinity Purified
Affinity Purified rabbit polyclonal IgG in PBS (without Mg2+ and Ca2+), pH 7.3 containing 0.5 mg/mL BSA (IgG, protease free) and 0.025% sodium azide and 50% glycerol.
Analysis Note
Control
Chick embryo fibroblast (CEF) cells expressing human wild-type Src protein
Chick embryo fibroblast (CEF) cells expressing human wild-type Src protein
Routinely evaluated by immunoblot.
Biochem/physiol Actions
Predicted to cross-react with Rat and Frog (100% homologous) based on sequence homology.
Recognizes Src phosphorylated on Tyrosine residue 418.
General description
60 kDa
Immunogen
Peptide corresponding to amino acid region encompassing the human, mouse, rat, chicken, and frog phospho-Src (Tyr418)
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Preparation Note
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Src: regulation, role in human carcinogenesis and pharmacological inhibitors.
Tsygankov, A Y and Shore, S K
Current Pharmaceutical Design, 10, 1745-1756 (2004)
Aida Habibovic et al.
JCI insight, 1(18), e88811-e88811 (2016-11-05)
Chronic inflammation with mucous metaplasia and airway remodeling are hallmarks of allergic asthma, and these outcomes have been associated with enhanced expression and activation of EGFR signaling. Here, we demonstrate enhanced expression of EGFR ligands such as amphiregulin as well
Functional stability of a mixed microbial consortium producing PHA from waste carbon sources.
Erik R Coats,Frank J Loge,William A Smith,David N Thompson,Michael P Wolcott
Applied Biochemistry and Biotechnology null
c-Src and cooperating partners in human cancer
Ishizawar, Rumey and Parsons, Sarah J
Cancer Cell, 6, 209-214 (2004)
Shinkyu Choi et al.
Antioxidants & redox signaling, 30(4), 505-519 (2018-01-18)
Altered redox state has been related to the development of normal pregnancy (NP) and preeclampsia (PE). Endothelial KCa2.3 and KCa3.1 (KCas) play an important role in vasodilation, and KCas levels are affected by oxidative stress. We investigated the mechanisms of
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