生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
human
种属反应性（根据同源性预测）
rat (100% homologous), mouse (100% homologous), rabbit (100% homologous)
制造商/商品名称
Upstate®
技术
western blot: suitable
同位素/亚型
IgG
NCBI登记号
UniProt登记号
运输
dry ice
靶向翻译后修饰
phosphorylation (pSer209)
基因信息
human ... EIF4E(1977)
特异性
Recognizes eIF4E phosphorylated on Ser209.
免疫原
KLH conjugated synthetic peptide corresponding to amino acids surrounding Ser209 of human eIF4E. Sequence conserved in mouse and rat.
应用
Anti-phospho eIF4E (Ser209) Antibody is an antibody against phospho eIF4E (Ser209) for use in WB.
Research Category
Signaling
Signaling
Research Sub Category
PI3K, Akt, & mTOR Signaling
RNA Binding Protein (RBP)
PI3K, Akt, & mTOR Signaling
RNA Binding Protein (RBP)
质量
Routinely evaluated by immunoblot.
目标描述
25 kDa
外形
ImmunoAffinity Purified
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Phosphorylation of eukaryotic initiation factor 4E (eIF4E) at Ser209 is not required for protein synthesis in vitro and in vivo
McKendrick, L, et al
European Journal of Biochemistry, 268, 5375-5385 (2001)
B Joshi et al.
The Journal of biological chemistry, 270(24), 14597-14603 (1995-06-16)
Initiation factor 4E (eIF-4E) binds to the m7GTP-containing cap of eukaryotic mRNA and facilitates the entry of mRNA into the initiation cycle of protein synthesis. eIF-4E is a phosphoprotein, and the phosphorylated form binds to mRNA caps 3-4-fold more tightly
A J Waskiewicz et al.
Molecular and cellular biology, 19(3), 1871-1880 (1999-02-18)
Eukaryotic translation initiation factor 4E (eIF4E) binds to the mRNA 5' cap and brings the mRNA into a complex with other protein synthesis initiation factors and ribosomes. The activity of mammalian eIF4E is important for the translation of capped mRNAs
Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA
Scheper, Gert C, et al
The Journal of Biological Chemistry, 277, 3303-3309 (2002)
Joanna Zuberek et al.
Biochemistry, 43(18), 5370-5379 (2004-05-05)
Eukaryotic translation initiation factor 4E (eIF4E) is essential for efficient protein synthesis in cap-dependent translation. The protein specifically binds the cap structure at the mRNA 5' terminus and facilitates the assembly of the mRNA with other initiation factors and the
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