生物来源
rabbit
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
rat, human
制造商/商品名称
Upstate®
技术
western blot: suitable
同位素/亚型
IgG
NCBI登记号
UniProt登记号
运输
dry ice
靶向翻译后修饰
phosphorylation (pSer539)
基因信息
human ... EIF2B5(8893)
特异性
Recognizes eIFB2ε phosphorylated on Ser539.
免疫原
KLH conjugated synthetic peptide corresponding to amino acids surrounding Ser539 of human eIF2Bε
应用
Anti-phospho-eIF2Bε (Ser539) Antibody is an antibody against phospho-eIF2Bε (Ser539) for use in WB.
质量
Routinely evaluated by immunoblot.
目标描述
82 kDa
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
S R Kimball et al.
The Journal of biological chemistry, 273(5), 3039-3044 (1998-02-28)
Modulation of protein/protein interaction is an important mechanism involved in regulation of translation initiation. Specifically, regulation of the interaction of eIF2 with the guanine nucleotide exchange factor, eIF2B, is a key mechanism for controlling translation under a variety of conditions.
N Price et al.
Biochimie, 76(8), 748-760 (1994-01-01)
Eukaryotic initiation factor eIF-2B catalyses the exchange of guanine nucleotides on another translation initiation factor, eIF-2, which itself mediates the binding of the initiator Met-tRNA to the 40S ribosomal subunit during translation initiation. eIF-2B promotes the release of GDP from
M Kleijn et al.
FEBS letters, 476(3), 262-265 (2000-07-29)
Epidermal and nerve growth factors (EGF and NGF) activate protein synthesis and initiation factor eIF2B in rat phaeochromocytoma (PC12) cells. The activation of protein synthesis by EGF or NGF depends upon extracellular regulated kinase kinase (MEK)/extracellular regulated kinase signalling. Here
L S Jefferson et al.
The international journal of biochemistry & cell biology, 31(1), 191-200 (1999-04-27)
Eukaryotic initiation factor eIF2B is a guanine nucleotide exchange protein involved in regulation of translation initiation. Phosphorylation of the epsilon-subunit is thought to be important in insulin-mediated changes in eIF2B activity. However, elucidation of insulin's action has proven elusive, primarily
Dynamic cycling of eIF2 through a large eIF2B-containing cytoplasmic body: implications for translation control
Campbell, S.G. et al.
The Journal of cell biology, 170(6), 925-934 (2005)
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