推荐产品
生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
human, mouse, rat
制造商/商品名称
Upstate®
技术
ELISA: suitable
western blot: suitable
同位素/亚型
IgG
NCBI登记号
UniProt登记号
运输
dry ice
靶向翻译后修饰
phosphorylation (pTyr412)
基因信息
human ... ABI1(10006)
mouse ... Abi1(11308)
rat ... Abi1(79249)
特异性
Other species have not been tested.
Recognizes both Abl and BCR-Abl when phosphorylated on tyrosine residue corresponding to Tyr412 in Abl.
免疫原
KLH-conjugated peptide corresponding to amino acid region encompassing human c-Abl Tyr412.
应用
Research Category
Signaling
Signaling
Research Sub Category
Cytoskeletal Signaling
General Post-translation Modification
Cytoskeletal Signaling
General Post-translation Modification
This Anti-phospho-Abl (Tyr412) Antibody is validated for use in ELISA, WB for the detection of phospho-Abl (Tyr412).
质量
Routinely evaluated by immunoblot.
目标描述
145 kDa
外形
ImmunoAffinity Purified
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
Wenjing Tao et al.
The Journal of biological chemistry, 289(31), 21463-21472 (2014-06-14)
Jak2 is involved in cytokine growth factor-stimulated signal transduction, but the mechanism of its activation is largely unknown. Here, we investigated Jak2 activation in a normal hematopoietic cell line, 32D mouse myeloid cells. The bimolecular fluorescence complementation studies showed that
Phosphoproteomic analysis of AML cell lines identifies leukemic oncogenes
Walters, Denise K, et al
Leukemia Research, 30, 1097-1104 (2006)
Phosphotyrosine mapping in Bcr/Abl oncoprotein using phosphotyrosine-specific immonium ion scanning
Steen, Hanno, et al
Molecular and Cellular Proteomics, 2, 138-145 (2003)
Jia Hu et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 30(2), 450-461 (2023-11-09)
This study sought to identify β-catenin targets that regulate desmoid oncogenesis and determine whether external signaling pathways, particularly those inhibited by sorafenib (e.g., PDGFRβ), affect these targets to alter natural history or treatment response in patients. In vitro experiments utilized
Tamara Marín et al.
Frontiers in cell and developmental biology, 10, 844297-844297 (2022-04-12)
Niemann-Pick type A (NPA) disease is a fatal lysosomal neurodegenerative disorder caused by the deficiency in acid sphingomyelinase (ASM) activity. NPA patients present severe and progressive neurodegeneration starting at an early age. Currently, there is no effective treatment for this
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