跳转至内容
Merck
CN
所有图片(1)

文件

07-758

Sigma-Aldrich

抗磷-Flt-1 (Tyr1213)抗体

Upstate®, from rabbit

登录查看公司和协议定价

别名:
Vascular endothelial growth factor receptor 1 (VEGFR-1), Vascular permeability factor receptor, Tyrosine-protein kinase FRT, Fms-like tyrosine kinase
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

rabbit

质量水平

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

纯化方式

affinity chromatography

种属反应性

bovine, human, goat, sheep, rat, mouse

制造商/商品名称

Upstate®

技术

western blot: suitable

同位素/亚型

IgG

NCBI登记号

UniProt登记号

运输

wet ice

靶向翻译后修饰

phosphorylation (pTyr1213)

基因信息

bovine ... Flt1(503620)
human ... FLT1(2321)
mouse ... Flt1(14254)
rat ... Flt1(54251)

特异性

识别磷酸-Flt-1 (Tyr1213)。

免疫原

KLH缀合的合成肽,包含序列(...VR[pY]VN...),其中[pY]对应于人Flt-1残基1213处的磷酸酪氨酸。免疫序列在狨猴中相同,在大鼠、山羊、绵羊、奶牛和恒河猴中有14/15个相同氨基酸,在小鼠中有13/15个相同氨基酸。

应用

抗磷酸-Flt-1 (Tyr1213)抗体可检测磷酸-Flt-1 (Tyr1213)水平 & 已发布 & 经验证可用于WB。
研究子范畴
生长因子 & 受体
研究类别
信号传导

质量

通过免疫印迹法对ATP孵育后磷酸化的重组Flt-1(目录号14-562)进行常规评估

目标描述

~180 kDa(QC检测片段为66 kDa)

外形

免疫亲和性纯化兔IgG ,溶于0.1 Tris-甘氨酸(pH 7.4)、0.15 NaCl和0.05%叠氮化钠中。
免疫亲和纯化

储存及稳定性

自收到之日起,在2-8°C条件下可稳定保存1年。 避免反复冻融循环,以免损坏IgG和影响产品性能。

分析说明

对照
重组Flt-1(目录号14-562)被ATP磷酸化

其他说明

浓度:请参考批次特异性浓缩物的检验报告。

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

WGK

WGK 1


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Paul Mésange et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 24(11), 2548-2558 (2018-03-02)
Purpose: There is extensive cross-talk between VEGF- and EGFR-pathway signaling in colorectal cancer. However, combinations of VEGF- and EGFR-targeted monoclonal antibodies (mAb) show disappointing activity, in particular for patients with mutant RAS Previous results show that tyrosine kinase inhibitors (TKI)
EGFR- and VEGF(R)-targeted small molecules show synergistic activity in colorectal cancer models refractory to combinations of monoclonal antibodies.
Poindessous, V; Ouaret, D; El Ouadrani, K; Battistella, A; Megalophonos, VF; Kamsu-Kom et al.
Clinical cancer research : an official journal of the American Association for Cancer Research null
Marga van de Vegte-Bolmer et al.
Malaria journal, 20(1), 381-381 (2021-09-28)
The ability to culture Plasmodium falciparum continuously in vitro has enabled stable access to asexual and sexual parasites for malaria research. The portfolio of isolates has remained limited and research is still largely based on NF54 and its derived clone
Zheng Zhou et al.
American journal of cancer research, 5(10), 3149-3161 (2015-12-23)
Angiogenesis is central to the growth of cancers and VEGFR-1/Flt-1 plays an important role during the neovascularization under pathological conditions. We previously founded a VEGFR1 antagonistic peptide, F56, by screening the phage peptide library. We showed that DHFR-F56 chimeric protein
Yoon-Jin Lee et al.
Cancer research, 70(21), 8357-8367 (2010-10-28)
Tumors induce new blood vessel growth primarily from host organ microvascular endothelial cells (EC), and microvasculature differs significantly between the lung and liver. Vascular endothelial growth factor (VEGF or VEGF-A) promotion of tumor angiogenesis is thought to be mediated primarily

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门