产品名称
Anti-cdk2 Antibody, Upstate®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CDK2AP1(8099)
Analysis Note
Control
Colon tissue
Colon tissue
routinely evaluated by immunoblot in nuclear extracts from HeLa cells
Application
Anti-cdk2 Antibody is a high quality Rabbit Polyclonal Antibody for the detection of cdk2 & has been validated in IP & WB.
Biochem/physiol Actions
Predicted to cross-react with mouse, rat, non-human primates, and hamster based on sequence homology
Recognizes human p33cdk2 protein kinase.
General description
33 kDa
Immunogen
peptide corresponding to amino acids 287-298 (C-QDVTKPVPHLRL) of human cdk2
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Format: Purified
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
C S Rani et al.
The Journal of biological chemistry, 272(16), 10777-10783 (1997-04-18)
Platelet-derived growth factor (PDGF) and serum, but not epidermal growth factor (EGF), stimulated sphingosine kinase activity in Swiss 3T3 fibroblasts and increased intracellular concentrations of sphingosine 1-phosphate (SPP), a sphingolipid second messenger (Olivera, A., and Spiegel, S. (1993) Nature 365
CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle.
Elledge, S J, et al.
Proceedings of the National Academy of Sciences of the USA, 89, 2907-2911 (1992)
Carlotta Costa et al.
Cancer discovery, 10(1), 72-85 (2019-10-09)
The combination of CDK4/6 inhibitors with antiestrogen therapies significantly improves clinical outcomes in ER-positive advanced breast cancer. To identify mechanisms of acquired resistance, we analyzed serial biopsies and rapid autopsies from patients treated with the combination of the CDK4/6 inhibitor
S J Elledge et al.
The EMBO journal, 10(9), 2653-2659 (1991-09-01)
The onset of S-phase and M-phase in both Schizosaccharomyces pombe and Saccharomyces cerevisiae requires the function of the cdc2/CDC28 gene product, p34, a serine-threonine protein kinase. A human homolog, p34cdc2, was identified by functional complementation of the S.pombe cdc2 mutation
Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants.
Restle, A; Farber, M; Baumann, C; Bohringer, M; Scheidtmann, KH; Muller-Tidow, C; Wiesmuller, L
Nucleic Acids Research null
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