产品名称
抗-二甲基精氨酸抗体，对称（SYM10）, serum, Upstate®
biological source
rabbit
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, human
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG
shipped in
dry ice
target post-translational modification
dimethylation (Arg)
Quality Level
Analysis Note
对照
阳性抗原对照：目录# 12-303，Jurkat细胞裂解液。
阳性抗原对照：目录# 12-303，Jurkat细胞裂解液。
通过免疫印迹对Jurkat细胞的RIPA裂解液进行了常规评估
Application
抗二甲基-精氨酸抗体，对称性（SYM10）是一种高质量的兔多克隆抗体，用于检测二甲基-精氨酸，&已在ICC、IP & WB中得到验证。
研究子类别
染色质生物学
染色质生物学
研究类别
信号传导
信号传导
Biochem/physiol Actions
识别含有多个对称二甲基化精氨酸的蛋白，包括p80-Coilin和Sm蛋白B、B′和D。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
不能识别非甲基化肽、含有不对称二甲基精氨酸的肽或含有单一对称二甲基精氨酸的肽。
变化
精氨酸甲基化是翻译后修饰，导致形成不对称和对称的二甲基化精氨酸（a-和sDMA）。
Immunogen
一种含有四个对称二甲基-精氨酸-甘氨酸重复序列的肽
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
含0.05％叠氮化钠和30％甘油的全兔抗血清。 在-20°C为液体形式。
Preparation Note
自收到之日起在-20°C可稳定保存1年。避免反复冻融。为了最大程度地回收产品，在融化后和取下盖子之前，将原始样品瓶进行离心。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Lindsay M Webb et al.
Frontiers in immunology, 10, 524-524 (2019-04-04)
Multiple sclerosis is an autoimmune disease of the central nervous system (CNS) mediated by CD4+ T cells and modeled via experimental autoimmune encephalomyelitis (EAE). Inhibition of PRMT5, the major Type II arginine methyltransferase, suppresses pathogenic T cell responses and EAE.
Hironari Tamiya et al.
The Journal of clinical investigation, 128(1), 517-530 (2017-12-12)
SHARPIN, an adaptor for the linear ubiquitin chain assembly complex (LUBAC), plays important roles in NF-κB signaling and inflammation. Here, we have demonstrated a LUBAC-independent role for SHARPIN in regulating melanoma growth. We observed that SHARPIN interacted with PRMT5, a
Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing.
Deng, X; Gu, L; Liu, C; Lu, T; Lu, F; Lu, Z; Cui, P; Pei, Y; Wang, B; Hu, S; Cao, X
Proceedings of the National Academy of Sciences of the USA null
Madhumitha Rengasamy et al.
Nucleic acids research, 45(19), 11106-11120 (2017-10-05)
We observed overexpression and increased intra-nuclear accumulation of the PRMT5/WDR77 in breast cancer cell lines relative to immortalized breast epithelial cells. Utilizing mass spectrometry and biochemistry approaches we identified the Zn-finger protein ZNF326, as a novel interaction partner and substrate
Joris Paris et al.
Retrovirology, 15(1), 48-48 (2018-07-13)
Nuclear localization of Gag is a property shared by many retroviruses and retrotransposons. The importance of this stage for retroviral replication is still unknown, but studies on the Rous Sarcoma virus indicate that Gag might select the viral RNA genome
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