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Merck
CN

07-402

抗p70 S6激酶抗体

Upstate®, from rabbit

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UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
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产品名称

抗p70 S6激酶抗体, Upstate®, from rabbit

biological source

rabbit

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse, rat

packaging

antibody small pack of 25 μg

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

Gene Information

human ... RPS6KB1(6198)

Analysis Note

通过免疫印迹对 HEK293、PC-12 和 A431 细胞的 RIPA 裂解液进行了常规评估

Application

抗 p70 S6 激酶抗体是针对 p70 S6 激酶的抗体,用于 IP & WB。
研究子类别
PI3K、Akt & mTOR 信号传导
研究类别
信号传导

Biochem/physiol Actions

p70 S6 激酶

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

64kda

Immunogen

对应于大鼠 p70 S6 激酶(具有 N 端半胱氨酸)氨基酸 26-43 的肽,

Other Notes

替代:04-391

Physical form

0.1M Tris-甘氨酸,pH 7.4,0.15M NaCl,0.05% 叠氮化钠,然后添加甘油至 30%
形式:纯化的
纯化的蛋白 A

Preparation Note

在 -20°C 条件下可保存 2 年

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

10 - Combustible liquids

wgk

WGK 2


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Protein phosphatase 2A inactivates the mitogen-stimulated S6 kinase from Swiss mouse 3T3 cells.
Ballou, L M, et al.
The Journal of Biological Chemistry, 263, 1188-1194 (1988)
A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation.
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Proceedings of the National Academy of Sciences of the USA, 89, 4052-4056 (1992)
Phosphotyrosine residues in the nerve-growth-factor receptor (Trk-A). Their role in the activation of inositolphospholipid metabolism and protein kinase cascades in phaeochromocytoma (PC12) cells.
Baxter, R M, et al.
European Journal of Biochemistry, 234, 84-91 (1995)
Zhiguang Xiao et al.
Oncotarget, 5(24), 12877-12890 (2014-11-07)
The presence of cancer stem cells (CSCs) is linked to preexisting or acquired drug resistance and tumor relapse. Therefore, targeting both differentiated tumor cells and CSCs was suggested as an effective approach for non-small cell lung cancer (NSCLC) treatment. After
Jason P Chua et al.
Human molecular genetics, 23(5), 1376-1386 (2013-10-24)
Spinobulbar muscular atrophy (SBMA) is an inherited neuromuscular disorder caused by the expansion of a CAG repeat encoding a polyglutamine tract in exon 1 of the androgen receptor (AR) gene. SBMA demonstrates androgen-dependent toxicity due to unfolding and aggregation of

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