07-377
抗核抗体
Upstate®, from rabbit
别名:
抗瓜氨酸化蛋白抗体
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Species reactivity:
human, vertebrates, mouse
Application:
IHC, WB
Citations:
21
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, vertebrates, mouse
manufacturer/tradename
Upstate®
technique(s)
immunohistochemistry: suitable, western blot: suitable
isotype
IgG
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
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General description
43-65 kDa
氨基酸瓜氨酸是肝脏从氨中解毒所必需的，氨是人体氧化的废物。瓜氨酸促进能量和帮助免疫系统。这种不寻常的氨基酸是在尿素循环中通过向鸟氨酸中加入二氧化碳和氨而形成的。接着与天冬氨酸结合形成精氨酸琥珀酸，然后被代谢成氨基酸精氨酸。
Immunogen
线状肽，含瓜氨酸。
Application
用抗瓜氨酸抗体（兔多克隆抗体）检测瓜氨酸，已证明可用于WB & IHC。
研究子类别
常规翻译后修改
常规翻译后修改
研究类别
炎症 & 免疫学
炎症 & 免疫学
Biochem/physiol Actions
人角质化皮肤中的多重脱位角蛋白。 在富含甘氨酸的环境中优先与瓜氨酸残基反应。
Physical form
25mM Tris/Tris-HCl，pH 7.4，137mM NaCl、2.7mM KCl、0.02%叠氮化钠，然后添加甘油至30％
免疫亲和纯化
Preparation Note
自收到之日起，在2-8°C条件下可稳定保存1年。
Analysis Note
对准
人外角化层全细胞裂解液
人外角化层全细胞裂解液
通过免疫印迹对带剥人角膜外层全细胞裂解液进行常规评估
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 1
A Ishida-Yamamoto et al.
The Journal of investigative dermatology, 114(4), 701-705 (2000-03-25)
Citrulline-containing proteins, mainly originating from keratin K1 and formed by enzymatic deimination of arginine residues, have been identified in the cornified layers of human epidermis. We analyzed the localization and nature of the deiminated proteins in psoriatic epidermis. Immunostaining based
Akemi Ishida-Yamamoto et al.
The Journal of investigative dermatology, 118(2), 282-287 (2002-02-14)
The final step of keratinocyte differentiation, transition from the granular cells to the cornified cells, involves various post-translational modifications that include deimination of arginine residues. Major deiminated epidermal proteins are derived from K1. Two preferred deimination sites were identified in
T Senshu et al.
Biochemical and biophysical research communications, 225(3), 712-719 (1996-08-23)
The upper layers of mammalian epidermis contain citrulline-containing proteins formed by enzymatic deimination of arginine residues. To study the role of protein deimination in epidermal differentiation, we identified deiminated proteins extracted from human epidermis. Major deiminated proteins were identified as
T Senshu et al.
Journal of dermatological science, 21(2), 113-126 (1999-10-08)
Citrulline residues are detected in keratins and filaggrin in the cornified layers of mammalian epidermis. Such citrulline residues are formed by the enzymatic deimination of arginine residues by peptidylarginine deiminases (EC 3.5.3.15). Major deiminated keratins are derived from keratin K1.
R Yu et al.
Scandinavian journal of immunology, 87(4), e12654-e12654 (2018-02-28)
Hypoxia is a prominent microenvironment feature in a range of disorders including cancer, rheumatoid arthritis (RA), atherosclerosis, inflammatory bowel disease (IBD), infection and obesity. Hypoxia promotes biological functions of fibroblast-like synoviocytes via regulating hypoxia-inducible factor 1α (HIF1α). Dysregulated protein citrullination
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