产品名称
抗乙酰组蛋白H2B抗体, Upstate®, from rabbit
biological source
rabbit
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
acetylation (Lys5,Lys12,Lys15,Lys20)
Quality Level
Gene Information
human ... H2BC1(255626)
Analysis Note
通过免疫印迹对经丁酸钠处理的HeLa细胞的酸提取蛋白进行了常规评估
Application
使用抗乙酰化组蛋白H2B抗体（兔多克隆抗体）检测乙酰化组蛋白H2B（也称为组蛋白H2B），经证明可在WB起作用。
研究子类别
组蛋白
组蛋白
研究类别
表观遗传学&核功能
表观遗传学&核功能
Biochem/physiol Actions
乙酰化组蛋白H2B
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
15 kDa
Immunogen
其中在人组蛋白H2B的5、12、15和20残基处有一个乙酰化赖氨酸的合成肽
Physical form
0.1M Tris-甘氨酸，pH 7.4，0.15M NaCl，0.05％ 叠氮化钠，然后添加甘油至30％
形式：纯化
蛋白A层析
Preparation Note
在-20°C下可保存2年
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
Estelle Schueller et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 33, 101-116 (2020-02-15)
Memory impairment is the main feature of Alzheimer's disease (AD). Initial impairments originate in the temporal lobe area and propagate throughout the brain in a sequential manner. Epigenetic mechanisms, especially histone acetylation, regulate plasticity and memory processes. These may be
Kelly L West et al.
Immunity, 23(2), 203-212 (2005-08-23)
V(D)J recombination is a tightly controlled process of somatic recombination whose regulation is mediated in part by chromatin structure. Here, we report that RAG2 binds directly to the core histone proteins. The interaction with histones is observed in developing lymphocytes
Spatial memory consolidation is associated with induction of several lysine-acetyltransferase (histone acetyltransferase) expression levels and H2B/H4 acetylation-dependent transcriptional events in the rat hippocampus.
Bousiges, O; Vasconcelos, AP; Neidl, R; Cosquer, B; Herbeaux, K; Panteleeva, I; Loeffler et al.
Neuropsychopharmacology null
Snehajyoti Chatterjee et al.
EMBO molecular medicine, 10(11) (2018-10-03)
Chromatin acetylation, a critical regulator of synaptic plasticity and memory processes, is thought to be altered in neurodegenerative diseases. Here, we demonstrate that spatial memory and plasticity (LTD, dendritic spine formation) deficits can be restored in a mouse model of
Yixin Dong et al.
Molecular and cellular biology, 37(19) (2017-07-12)
Global histone hyperacetylation is suggested to play a critical role for replacement of histones by transition proteins and protamines to compact the genome during spermiogenesis. However, the underlying mechanisms for hyperacetylation-mediated histone replacement remains poorly understood. Here, we report that
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