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Merck
CN
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文件

07-227

Sigma-Aldrich

Anti-p34-Arc/ARPC2 Antibody

Upstate®, from rabbit

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UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

rabbit

质量水平

抗体产品类型

primary antibodies

克隆

polyclonal

种属反应性

mouse, human

制造商/商品名称

Upstate®

技术

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

同位素/亚型

IgG

NCBI登记号

UniProt登记号

运输

dry ice

基因信息

human ... ARPC2(10109)

特异性

Recognizes p34-Arc/ARPC2 of the Arp2/3 complex.

免疫原

Peptide corresponding to amino acids 285-298 of human Arc

应用

Anti-p34-Arc/ARPC2 Antibody detects level of p34-Arc/ARPC2 & has been published & validated for use in IC, IH & WB.
Research Category
Cell Structure
Research Sub Category
Cytoskeleton

质量

routinely evaluated by immunoblot on RIPA lysates from human A431, Jurkat, and mouse 3T3 cells

目标描述

34 kDa

外形

Protein A purified
Format: Purified
Protein A Purified immunoglobulin in 0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide and 30% glycerol.

储存及稳定性

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

分析说明

Control
Positive Control Included: Non-Stim A431 Cell Lysate (12-301)

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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The role of Arp2/3 in growth cone actin dynamics and guidance is substrate dependent.
San Miguel-Ruiz, JE; Letourneau, PC
The Journal of Neuroscience null
Organization of the Arp2/3 complex in hippocampal spines.
Racz, B; Weinberg, RJ
The Journal of Neuroscience null
Formation of adherens junctions leads to the emergence of a tissue-level tension in epithelial monolayers.
Harris, AR; Daeden, A; Charras, GT
Journal of Cell Science null
Structural basis for regulation of Arp2/3 complex by GMF.
Luan, Q; Nolen, BJ
Nature Structural and Molecular Biology null
Vera Dugina et al.
Oncotarget, 6(16), 14556-14571 (2015-05-27)
Here we have shown that β-cytoplasmic actin acts as a tumor suppressor, inhibiting cell growth and invasion in vitro and tumor growth in vivo. In contrast, γ-cytoplasmic actin increases the oncogenic potential via ERK1/2, p34-Arc, WAVE2, cofilin1, PP1 and other

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