Anti-G3BP1 Antibody

G3BP1 (Ras-GTPase activating protein SH3-domain binding protein 1) directly associates with SH3 domains of GTPase activating proteins (GAPs). It was first discovered by its binding to RasGAP. G3BPs have been shown to be involved in a number of mitogenic signaling pathways. G3BP1 is also known to be over expressed in many human cancers (Kim, 2007) and its expression appears to be inversely correlated with PTEN expression (Kim, 2007). Interestingly, G3BP1, along with G3BP2, has been shown to bind to the C-terminus of p53, playing a crucial role in its activity (Kim, 2007). Furthermore, the G3BPs have two traditional RNA binding motifs.

Not tested on other species.

This antibody detects G3BP1 at its C-terminal region.

Epitope: C-terminus

Synthetic peptide corresponding to C-terminal region of human G3BP1.

Anti-G3BP1 Antibody detects level of G3BP1 & has been published & validated for use in WB & IP.

Research Category
Signaling

Research Sub Category
RNA Binding Protein (RBP)

Evaluated by western blot on HeLa cell lysates.

Western Blot Analysis:
1:1,000 dilution of this antibody was used to detect G3BP1 in HeLa, 293T and S10 cell lysates.

68 kDa

Rabbit polyclonal serum with 0.05% NaN3.

Stable for 1 year at -20ºC from date of receipt.

Control
HeLa cell lysates.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.