07-1512
Anti-phospho-WAVE2 (Ser343) Antibody
from rabbit, purified by affinity chromatography
别名:
SCAR2, WASF2, dJ393P12.2, WASP family protein member 2, Protein WAVE-2, Verprolin homology domain-containing protein 2
产品名称
Anti-phospho-WAVE2 (Ser343) Antibody, from rabbit, purified by affinity chromatography
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, monkey
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
phosphorylation (pSer343)
Gene Information
human ... WASF2(10163)
Analysis Note
Control
COS-7+EGF cell lysates untreated and lambda phosphatase treated.
COS-7+EGF cell lysates untreated and lambda phosphatase treated.
Evaluated by Western Blot in COS-7+EGF cell lysates untreated and lambda phosphatase-treated.
Western Blot Analysis: A 1:500 dilution of this antibody detected phospho-WAVE2 (Ser343) in 10 µg of COS-7+EGF cell lysates untreated and lambda phosphatase treated.
Western Blot Analysis: A 1:500 dilution of this antibody detected phospho-WAVE2 (Ser343) in 10 µg of COS-7+EGF cell lysates untreated and lambda phosphatase treated.
Application
Anti-phospho-WAVE2 (Ser343) Antibody detects level of phospho-WAVE2 (Ser343) & has been published & validated for use in WB.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Cytoskeletal Signaling
Cytoskeletal Signaling
Western Blot Analysis: A previous lot of this antibody was used to detect endogenous phospho-WAVE2 (Ser343) in COS-7 and HMECs following EGF stimulation ± pretreatment with U0126 (Mendoza, M.C., et al. (2011). Mol Cell. 41(6):661-671).
Biochem/physiol Actions
This antibody recognizes WAVE2 phosphorylated at Ser343.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Wiskott-Aldrich Syndrome Protein (WASP)-family Protein Member 2 (known as WAVE2) is found in many cells and tissues, with strong expression in peripheral blood leukocytes. WAVE2 is involved in signaling RTKs and small GTPases. As a whole, the WAVE family of proteins have a general function for regulating the actin cytoskeleton in various tissues.
~75 kDa observed.
An uncharacterized band appears at ~103 kDa in some lysates.
An uncharacterized band appears at ~103 kDa in some lysates.
Immunogen
Epitope: Phosphorylated Ser343
KLH-conjugated linear peptide corresponding to human WAVE2 phosphorylated at Ser343.
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex.
Mendoza, MC; Er, EE; Zhang, W; Ballif, BA; Elliott, HL; Danuser, G; Blenis, J
Molecular Cell null
Sascha Gromnitza et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(3), 1665-1676 (2017-11-23)
Podocyte malfunction is central to glomerular diseases and is marked by defective podocyte intercellular junctions and actin cytoskeletal dynamics. Podocytes share many morphologic features with neurons, so that similar sets of proteins appear to regulate cell process formation. One such
Andrea Palamidessi et al.
Nature materials, 18(11), 1252-1263 (2019-07-25)
During wound repair, branching morphogenesis and carcinoma dissemination, cellular rearrangements are fostered by a solid-to-liquid transition, known as unjamming. The biomolecular machinery behind unjamming and its pathophysiological relevance remain, however, unclear. Here, we study unjamming in a variety of normal
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