07-1497
抗-cAMP抗体
serum, from rabbit
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Species reactivity:
rat
Application:
immunohistochemistry
Technique(s):
immunohistochemistry: suitable (paraffin)
Citations:
8
产品名称
抗-cAMP抗体, serum, from rabbit
biological source
rabbit
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat
species reactivity (predicted by homology)
all
technique(s)
immunohistochemistry: suitable (paraffin)
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Analysis Note
对照
大鼠海马和小脑组织
大鼠海马和小脑组织
已通过免疫组织化学在大鼠海马和小脑组织中进行评估。
免疫组织化学分析：该批次1:100稀释液在大鼠海马和小脑组织中检测到cAMP。
免疫组织化学分析：该批次1:100稀释液在大鼠海马和小脑组织中检测到cAMP。
Application
抗cAMP抗体可检测cAMP水平 & 已出版&并经过验证可用于IH(P)。
研究子类别
GPCR, cAMP/cGMP & 钙信号传导
GPCR, cAMP/cGMP & 钙信号传导
研究类别
信号传导
信号传导
Biochem/physiol Actions
对cAMP具有特异性，在浓度至1 mM时与其他核苷酸无交叉反应。与固定在组织中的cAMP或乙酰化的cAMP反应。在RIA或EIA分析中，与游离的非乙酰化cAMP不反应。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
当G蛋白偶联受体（GPCR）结合细胞表面上的各种配体时，环磷酸腺苷或cAMP是腺苷环化酶ATP的细胞内副产物。环AMP充当跨细胞膜的信号转导的第二信使，并且是激酶激活的一部分。它调节胰高血糖素和肾上腺素的作用以及钙离子通过离子通道的运动。由于它直接受GPCR激活的影响，因此在发现治疗药物时将cAMP作为监测GPCR的一种手段进行研究。
Immunogen
结合BSA的2′O-琥珀酰环AMP
Other Notes
替代：MABN1026
Physical form
未纯化的兔血清
稀释的血清在不含防腐剂的PBS中以液体形式呈现。
Preparation Note
自收到之日起，未稀释的等分试样在-20°C下保存。应避免反复冻/融循环。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Enterotoxigenic Escherichia coli secretes a highly conserved mucin-degrading metalloprotease to effectively engage intestinal epithelial cells.
Luo, Q; Kumar, P; Vickers, TJ; Sheikh, A; Lewis, WG; Rasko, DA; Sistrunk, J; Fleckenstein, JM
Infection and Immunity null
Melody Atkins et al.
Nature communications, 14(1), 8003-8003 (2023-12-05)
Directed cell migration requires sustained cell polarisation. In migrating cortical interneurons, nuclear movements are directed towards the centrosome that organises the primary cilium signalling hub. Primary cilium-elicited signalling, and how it affects migration, remain however ill characterised. Here, we show
Marie Helene Schernthaner-Reiter et al.
Human molecular genetics, 29(17), 2951-2961 (2020-08-22)
Mutations of the regulatory subunit (PRKAR1A) of the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA), leading to activation of the PKA pathway, are the genetic cause of Carney complex which is frequently accompanied by somatotroph tumors. Aryl hydrocarbon receptor-interacting protein
Beatriz Martínez-Rojas et al.
Cellular and molecular life sciences : CMLS, 79(8), 455-455 (2022-07-30)
Neural progenitor cell (NPC) transplantation represents a promising treatment strategy for spinal cord injury (SCI); however, the underlying therapeutic mechanisms remain incompletely understood. We demonstrate that severe spinal contusion in adult rats causes transcriptional dysregulation, which persists from early subacute
Robbert Havekes et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(34), 8936-8946 (2016-08-26)
Alterations in cAMP signaling are thought to contribute to neurocognitive and neuropsychiatric disorders. Members of the cAMP-specific phosphodiesterase 4 (PDE4) family, which contains >25 different isoforms, play a key role in determining spatial cAMP degradation so as to orchestrate compartmentalized
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