生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
human
种属反应性（根据同源性预测）
dog (expected based only 1 amino acid difference), horse (expected based only 1 amino acid difference), primate (expected based only 1 amino acid difference), bovine (expected based only 1 amino acid difference)
制造商/商品名称
Upstate®
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
phosphorylation (pSer81)
基因信息
bovine ... Ar(280675)
dog ... Ar(403588)
human ... AR(367)
一般描述
X连锁雄激素受体（二氢睾酮受体；核受体亚家族3 C组成员4）是NR3配体依赖性转录因子家族的成员，其特征在于C末端的配体结合结构域、中央DNA结合结构域和N末端转录激活结构域。 雄激素受体被类固醇激素如睾酮和二氢睾酮激活。活化的雄激素受体从细胞质转移到细胞核，它们形成结合DNA的同型二聚体。雄激素受体与许多衔接子样蛋白结合，并作为复合物起作用，该复合物可以诱导或抑制转录，这取决于其相关蛋白是可能通过修饰染色质影响转录的共激活因子还是共抑制因子。共激活因子参与组蛋白乙酰化和转录激活，而共抑制因子参与组蛋白去乙酰化和转录抑制。雄激素受体对于确定性别和雄性特征很重要。缺陷的雄激素受体可能在Reifenstein综合征，肯尼迪病以及前列腺癌中起作用。
特异性
仅在Ser81磷酸化后检测雄激素受体（AR）
免疫原
对应于人雄激素受体Ser81及其周围氨基酸的KLH结合合成肽。
应用
抗磷酸雄激素受体（Ser81）抗体是一种针对磷酸雄激素受体（Ser81）的抗体，用于WB。
研究子类别
转录因子
转录因子
研究类别
信号传导
表观遗传学&核功能
信号传导
表观遗传学&核功能
质量
通过蛋白质印迹对R1881（甲雌三烯醇酮）处理的LNCap裂解液进行了常规评估
目标描述
110 kDa
外形
纯化的兔多克隆抗体，溶于含有0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05％叠氮化钠的缓冲液中。
储存及稳定性
自收到之日起在2-8°C可稳定保存1年。
处理建议：收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。避免反复冻融，其可能会破坏IgG并影响产品性能。
处理建议：收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。避免反复冻融，其可能会破坏IgG并影响产品性能。
分析说明
对照
R1881（甲三烯醇酮）处理的LNCap裂解液
R1881（甲三烯醇酮）处理的LNCap裂解液
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Kazumasa Komura et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(22), 6259-6264 (2016-05-18)
The androgen receptor (AR) plays an essential role in prostate cancer, and suppression of its signaling with androgen deprivation therapy (ADT) has been the mainstay of treatment for metastatic hormone-sensitive prostate cancer for more than 70 y. Chemotherapy has been
J M Willder et al.
British journal of cancer, 108(1), 139-148 (2013-01-17)
Prostate cancer cell growth is dependent upon androgen receptor (AR) activation, which is regulated by specific kinases. The aim of the current study is to establish if AR phosphorylation by Cdk1 or ERK1/2 is of prognostic significance. Scansite 2.0 was
Nooshin Mirkheshti et al.
Oncotarget, 7(38), 62240-62254 (2016-08-25)
Androgen receptor (AR) and PI3K/AKT/mTORC1 are major survival signals that drive prostate cancer to a lethal disease. Reciprocal activation of these oncogenic pathways from negative cross talks contributes to low/limited success of pathway-selective inhibitors in curbing prostate cancer progression. We
Ralph E White et al.
Frontiers in oncology, 13, 1210487-1210487 (2023-07-17)
Prostate cancer (PCa) remains the most diagnosed non-skin cancer amongst the American male population. Treatment for localized prostate cancer consists of androgen deprivation therapies (ADTs), which typically inhibit androgen production and the androgen receptor (AR). Though initially effective, a subset
Androgen receptor phosphorylation at serine 81 and serine 213 in castrate-resistant prostate cancer.
Milly J McAllister et al.
Prostate cancer and prostatic diseases, 23(4), 596-606 (2020-05-03)
Despite increases in diagnostics and effective treatments, over 300,000 men die from prostate cancer highlighting the need for specific and differentiating biomarkers. AR phosphorylation associates with castrate-resistance, with pARser213 promoting transcriptional activity. We hypothesise that combined pARser81 and pARser213 reduces
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