07-1341
抗PHLPP1抗体
from rabbit, purified by affinity chromatography
别名:
PH domain and leucine rich repeat protein phosphatase, PH domain leucine-rich repeat protein phosphatase, Pleckstrin homology domain-containing family E protein 1, SCN circadian oscillatory protein, Suprachiasmatic nucleus circadian oscillatory protein
产品名称
抗PHLPP1抗体, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
conjugate
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
liquid
purified by
affinity chromatography
species reactivity
rat, mouse, human
technique(s)
immunocytochemistry: suitable
western blot: suitable
immunogen sequence
KLH-conjugated linear peptide corresponding to the C-terminus of PHLPP1.
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
Quality Level
Gene Information
human ... PHLPP1(23239)
Analysis Note
对照
人脑组织裂解液
人脑组织裂解液
通过蛋白质印迹在人脑组织裂解物中进行了评估。
蛋白质印迹分析：该抗体的1：1,000稀释液可在人脑组织裂解液中检测到PHLPP1。
蛋白质印迹分析：该抗体的1：1,000稀释液可在人脑组织裂解液中检测到PHLPP1。
Application
抗PHLPP1抗体检测PHLPP1的水平 & 已发布 & 经验证可用于WB & IC。
研究子类别
PI3K、Akt & mTOR 信号传导
PI3K、Akt & mTOR 信号传导
研究类别
信号传导
信号传导
Biochem/physiol Actions
该抗体可识别PHLPP1的C端。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
134 kDa 在110 kDa下观察
PHLPP1是负责Akt (Ser473)位点去磷酸化的蛋白磷酸酶。Akt (Ser473)是TORC2 (mTOR)磷酸化激活位点。
Immunogen
KLH偶联的线性肽，对应于PHLPP1的C端。
表位：C端
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
亲和纯化
纯化的兔血清，溶于含有0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05％叠氮化钠的缓冲液中。
Preparation Note
自接收之日起，在2-8°C下冷藏保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Travis C Jackson et al.
Scientific reports, 5, 9377-9377 (2015-04-02)
Pleckstrin homology domain and leucine rich repeat protein phosphatase 1 (PHLPP1) is a member of the serine/threonine family of phosphatases. It has been studied in organs including brain, heart, pancreas, adipose, breast, and prostate. Human PHLPP1 encodes two splice variants
Saida Abdelli et al.
PloS one, 7(5), e35997-e35997 (2012-05-09)
We have recently shown that silencing of the brain/islet specific c-Jun N-terminal Kinase3 (JNK3) isoform enhances both basal and cytokine-induced beta-cell apoptosis, whereas silencing of JNK1 or JNK2 has opposite effects. While it is known that JNK1 or JNK2 may
Georgia Balsevich et al.
Nature communications, 8(1), 1725-1725 (2017-11-25)
The co-chaperone FKBP5 is a stress-responsive protein-regulating stress reactivity, and its genetic variants are associated with T2D related traits and other stress-related disorders. Here we show that FKBP51 plays a role in energy and glucose homeostasis. Fkbp5 knockout (51KO) mice
Clara M Castillejo Becerra et al.
Journal of cellular biochemistry, 119(9), 7470-7478 (2018-05-19)
The protein phosphatase Phlpp1 is an essential enzyme for proper chondrocyte function. Altered Phlpp1 levels are associated with cancer and degenerative diseases such as osteoarthritis. While much is known about the post-transcriptional mechanisms controlling Phlpp1 levels, transcriptional regulation of the
A molecular brake controls the magnitude of long-term potentiation.
Wang, Y; Zhu, G; Briz, V; Hsu, YT; Bi, X; Baudry, M
Nature Communications null
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