Anti-IGF2BP1/2 Antibody

Insulin-like growth factor 2 mRNA-binding proteins are RNA-binding factors belonging to the IMP (IGF-II mRNA-binding protein) family of proteins. These proteins contain four K homology domains and two RNA recognition motifs. IGF2BP′s have key roles in regulating the translation of target mRNAs. For the insulin-like growth factor 2 (IGF2) gene, IGF2BP′s bind to the 5′ UTR of the mRNA and regulate translation. IGF2BP′s are expressed in a variety of fetal tissues such as; follicles in ovary, liver, lung, kidney, thymus, placenta. Expression has also been observed in the gonoocytes of testis, oocytes, semen, spermatagonia and in several cancers including; testicular, lung, kidney, trachea, and prostate.

This antibody recognizes IGF2BP1 and IGFBP2 at the C-terminus.

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to human IGF2BP1/2 at the C-terminus.

Anti-IGF2BP1/2 Antibody is a Rabbit Polyclonal Antibody for detection of IGF2BP1/2 also known as Hepatocellular carcinoma autoantigen p62, IGF2 mRNA-binding protein 2 & has been validated in WB & IP.

Research Category
Apoptosis & Cancer

Research Sub Category
RNA Metabolism & Binding Proteins

RNA Metabolism & Binding Proteins

Western Blot (SNAP ID) Analysis: 4 µg/mL from a representative lot detected IGF2BP1/2 on 10 µg of HEK293 cell lysate.

Immunoprecipitation Analysis: 4 µg/mL from a representative lot was used by an independent laboratory in IP.

Evaluated by Western Blot in HEK293 cell lysate.

Western Blot Analysis: 0.1 µg/mL of this antibody detected IGF2BP1/2 on 10 µg of HEK293 cell lysate.

~63 kDa observed. Reactivity has been observed for both IGF2BP1 and IGF2BP2

Affinity purified

Purified rabbit polyclonal containing PBS with 0.09% azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
HEK293 cell lysate

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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