07-1014
Anti-Upf1 Antibody
from rabbit
别名:
ATP-dependent helicase RENT1, Nonsense mRNA reducing factor 1, UP Frameshift 1, UPF1 regulator of nonsense transcripts homolog (yeast), Up-frameshift suppressor 1 homolog, delta helicase, regulator of nonsense transcripts 1, up-frameshift mutation 1 homo
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所有图片(1)
About This Item
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
human
种属反应性（根据同源性预测）
mouse, bovine, canine, rat
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... UPF1(5976)
一般描述
Upf1 is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. Upf1 is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping.
特异性
This antibody detects Upf1.
免疫原
KLH-conjugated synthetic linear peptide corresponding to Upf1.
应用
Anti-Upf1 Antibody is a rabbit polyclonal antibody for detection of Upf1 also known as ATP-dependent helicase RENT1 ,Nonsense mRNA reducing factor 1, Up-frameshift suppressor 1 homolog & has been validated in WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
RNA Binding Protein (RBP)
RNA Binding Protein (RBP)
质量
Evaluated by western blot on U2OS cell lysate.
Western Blot Analysis: 0.5-2 µg/mL of this antibody detected Upf1 in U2OS cell lysate.
Western Blot Analysis: 0.5-2 µg/mL of this antibody detected Upf1 in U2OS cell lysate.
目标描述
~125 kDa
外形
Affinity purified
Format: Purified
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
储存及稳定性
Stable for 1 year at 2-8ºC from date of receipt.
分析说明
Control
U2OS cell lysate
U2OS cell lysate
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
Catia Andreassi et al.
Cell reports, 34(8), 108778-108778 (2021-02-25)
The 3' untranslated regions (3' UTRs) of messenger RNAs (mRNAs) are non-coding sequences involved in many aspects of mRNA metabolism, including intracellular localization and translation. Incorrect processing and delivery of mRNA cause severe developmental defects and have been implicated in
Gabriel Sanchez et al.
Nucleic acids research, 44(6), 2661-2676 (2015-12-15)
Loss of 'Survival of Motor Neurons' (SMN) leads to spinal muscular atrophy (SMA), a disease characterized by degeneration of spinal cord alpha motor neurons, resulting in muscle weakness, paralysis and death during early childhood. SMN is required for assembly of
Bonnie R Fletcher et al.
Neurobiology of learning and memory, 115, 58-67 (2014-08-26)
Memory decline is a common feature of aging. Expression of the immediate-early gene Arc is necessary for normal long-term memory, and although experience dependent Arc transcription is reportedly reduced in the aged rat hippocampus, it has not been clear whether
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