推荐产品
生物来源
rabbit
质量水平
抗体形式
affinity purified immunoglobulin
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
human, mouse, rat
制造商/商品名称
Upstate®
技术
western blot: suitable
同位素/亚型
IgG
NCBI登记号
UniProt登记号
运输
dry ice
靶向翻译后修饰
phosphorylation (pThr187)
基因信息
human ... CDKN1B(1027)
特异性
磷酸化Kip1
免疫原
对应于人Kip1氨基酸179-190的KLH偶联合成肽(C-PNAGSVEQ[pT]PKK)
应用
抗磷酸化-Kip1(Thr187)抗体是一种高质量的兔多克隆抗体,用于检测 磷酸化-Kip1(Thr187),&已在 WB 中验证。
研究子类别
细胞周期,DNA 复制&修复
细胞周期,DNA 复制&修复
研究类别
表观遗传学&核功能
表观遗传学&核功能
质量
通过免疫印迹法对HeLa 细胞RIPA裂解液进行了常规评估
目标描述
27kDa
外形
0.2M Tris、0.15M NaCl、0.1mM EDTA、0.05%叠氮化钠,然后添加甘油至30%
免疫亲和层析
储存及稳定性
在-20°C下保存1年
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
p27KIP1, an inhibitor of cyclin-dependent kinases.
Koff, A and Polyak, K
Progress in Cell Cycle Research, 1, 141-147 (1995)
Oncostatin M induces growth arrest by inhibition of Skp2, Cks1, and cyclin A expression and induced p21 expression.
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Cancer Research null
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Frontiers in bioscience : a journal and virtual library, 4, D787-D792 (1999-11-30)
The first gap phase (G1) in the mammalian cell cycle plays a pivotal role in determining whether or not cells are to initiate DNA replication. Progression through G1 phase and transition into S phase are positively and negatively regulated by
Shuichan Xu et al.
The Journal of biological chemistry, 282(21), 15462-15470 (2007-04-06)
p27, an important cell cycle regulator, blocks the G(1)/S transition in cells by binding and inhibiting Cdk2/cyclin A and Cdk2/cyclin E complexes (Cdk2/E). Ubiquitination and subsequent degradation play a critical role in regulating the levels of p27 during cell cycle
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British journal of cancer, 93(2), 208-215 (2005-07-07)
Easily accessible normal tissues expressing the same molecular site(s) of drug action as malignant tissue offer an enhanced potential for early proof of anticancer drug mechanism and estimation of the biologically effective dose. Studies were undertaken in healthy male volunteers
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