生物来源
rabbit
质量水平
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
mouse, human
制造商/商品名称
Upstate®
技术
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型
IgG
NCBI登记号
UniProt登记号
运输
dry ice
靶向翻译后修饰
unmodified
基因信息
human ... MPL(4352)
mouse ... Mpl(17480)
特异性
糖基化和非糖基化TPO受体/c-Mpl
免疫原
KLH偶联的合成肽，对应于人TPO（促血小板生成素）受体（C-ANHSYLPLSYWQQP）的氨基酸。
应用
抗-TPOR/c-Mpl抗体是一种抗TPOR/c-Mpl的抗体，用于IP、WB、IH。
研究子范畴
生长因子 & 受体
生长因子 & 受体
研究类别
信号传导
信号传导
质量
通过免疫印迹对DAMI细胞的RIPA裂解液进行了常规评估
目标描述
68.5 kDa（计算值）
外形
0.1M Tris-甘氨酸，pH 7.4，0.15M NaCl，0.05％叠氮化钠，然后添加甘油至30％
形式：纯化
蛋白A层析
储存及稳定性
在-20°C下可保存2年
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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WGK
WGK 1
Reiji Nozaki et al.
Hepatology research : the official journal of the Japan Society of Hepatology, 43(6), 610-620 (2012-11-20)
Liver cirrhosis (LC) is the end stage of chronic liver disease. No definitive pharmacological treatment is currently available. We previously reported that thrombopoietin (TPO) promoted liver regeneration and improved liver cirrhosis by increasing platelet count. TPO is therefore considered to
Cédric Cleyrat et al.
Traffic (Copenhagen, Denmark), 15(9), 961-982 (2014-06-17)
Myeloproliferative neoplasms (MPNs) are often characterized by JAK2 or calreticulin (CALR) mutations, indicating aberrant trafficking in pathogenesis. This study focuses on Mpl trafficking and Jak2 association using two model systems: human erythroleukemia cells (HEL; JAK2V617F) and K562 myeloid leukemia cells
Norma E Fox et al.
Experimental hematology, 37(4), 495-503 (2009-03-24)
To genetically and functionally characterize mutations of c-Mpl that lead to thrombocytopenia in a child with congenital amegakaryocytic thrombocytopenia. We identified two c-Mpl mutations in a child with clinical features of congenital amegakaryocytic thrombocytopenia, one a previously described mutation in
A R Moliterno et al.
Blood, 94(8), 2555-2561 (1999-10-09)
Recently, we demonstrated a marked reduction in the expression of the thrombopoietin receptor, Mpl, in polycythemia vera (PV) platelets and megakaryocytes using an antiserum against the Mpl extracellular domain. To further examine this abnormality, we raised an antibody to the
Melanie Märklin et al.
Journal of cellular and molecular medicine, 24(21), 12491-12503 (2020-09-22)
Thrombocyte formation from megakaryocyte and their progenitor cells is tightly regulated by thrombopoietin (TPO) and its receptor c-MPL, thereby maintaining physiological functionality and numbers of circulating platelets. In patients, dysfunction of this regulation could cause thrombocytopenia or myeloproliferative syndromes. Since
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