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Merck
CN
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文件

06-891

Sigma-Aldrich

Anti-SMRTe Antibody

Upstate®, from rabbit

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别名:
Anti-CTG26, Anti-N-CoR2, Anti-SMAP270, Anti-SMRT, Anti-SMRTE, Anti-SMRTE-tau, Anti-TNRC14, Anti-TRAC, Anti-TRAC-1, Anti-TRAC1
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

rabbit

质量水平

抗体形式

purified antibody

抗体产品类型

primary antibodies

克隆

polyclonal

种属反应性

human

制造商/商品名称

Upstate®

技术

ChIP: suitable
immunocytochemistry: suitable
western blot: suitable

同位素/亚型

IgG

NCBI登记号

UniProt登记号

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

一般描述

SMRT is 1495 amino acids and contains an 8 amino acid sequence that is not present in SMRTe (SMRT-extended), which contains 2514 amino acids. SMRTe contains an N-terminal sequence spanning over 1,000 amino acids that is not present in SMRT, but that shows significant similarity with N-CoR. SMRTe expression is regulated during cell cycle progression, suggesting a role for SMRTe in the regulation of cycle-specific gene expression in diverse signaling pathways.

特异性

SMRT isoforms

免疫原

GST fusion-protein corresponding to residues 1146-1349 of human SMRTe

应用

Anti-SMRTe Antibody is a high quality Rabbit Polyclonal Antibody for the detection of SMRTe & has been validated in ChIP, ICC & WB.
Research Category
Protein Trafficking

Epigenetics & Nuclear Function
Research Sub Category
RNA Metabolism & Binding Proteins

Histones

RNA Binding Protein (RBP)

质量

routinely evaluated by immunoblot on nuclear fraction from murine brain

目标描述

270kDa, 180kDa and 80kDa

外形

Protein A chromatography
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified

储存及稳定性

Store at 2–8°C

分析说明

Control
Mouse brain nuclear extract

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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TGF-? and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells.
Takahashi, H; Kanno, T; Nakayamada, S; Hirahara, K; Sciume, G; Muljo, SA; Kuchen et al.
Nature Immunology null
The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT.
Takahashi, S; McConnell, MJ; Harigae, H; Kaku, M; Sasaki, T; Melnick, AM; Licht, JD
Blood null
SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers.
Chen, J D, et al.
Proceedings of the National Academy of Sciences of the USA, 93, 7567-7571 (1996)
NCoR1 and SMRT play unique roles in thyroid hormone action in vivo.
Shimizu, H; Astapova, I; Ye, F; Bilban, M; Cohen, RN; Hollenberg, AN
Molecular and cellular biology null
Hiroaki Shimizu et al.
PloS one, 14(8), e0220717-e0220717 (2019-08-14)
Silencing Mediator of Retinoid and Thyroid Hormone Receptors (SMRT) and the nuclear receptor co-repressor1 (NCoR1) are paralogs and regulate nuclear receptor (NR) function through the recruitment of a multiprotein complex that includes histone deacetylase activity. Previous genetic strategies which deleted

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