推荐产品
生物来源
rabbit
质量水平
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
human
制造商/商品名称
Upstate®
技术
ChIP: suitable
immunocytochemistry: suitable
western blot: suitable
同位素/亚型
IgG
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... NCOR2(9612) , TRAC(28755)
一般描述
SMRT is 1495 amino acids and contains an 8 amino acid sequence that is not present in SMRTe (SMRT-extended), which contains 2514 amino acids. SMRTe contains an N-terminal sequence spanning over 1,000 amino acids that is not present in SMRT, but that shows significant similarity with N-CoR. SMRTe expression is regulated during cell cycle progression, suggesting a role for SMRTe in the regulation of cycle-specific gene expression in diverse signaling pathways.
特异性
SMRT isoforms
免疫原
GST fusion-protein corresponding to residues 1146-1349 of human SMRTe
应用
Anti-SMRTe Antibody is a high quality Rabbit Polyclonal Antibody for the detection of SMRTe & has been validated in ChIP, ICC & WB.
Research Category
Protein Trafficking
Epigenetics & Nuclear Function
Protein Trafficking
Epigenetics & Nuclear Function
Research Sub Category
RNA Metabolism & Binding Proteins
Histones
RNA Binding Protein (RBP)
RNA Metabolism & Binding Proteins
Histones
RNA Binding Protein (RBP)
质量
routinely evaluated by immunoblot on nuclear fraction from murine brain
目标描述
270kDa, 180kDa and 80kDa
外形
Protein A chromatography
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
储存及稳定性
Store at 2–8°C
分析说明
Control
Mouse brain nuclear extract
Mouse brain nuclear extract
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
TGF-? and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells.
Nature Immunology null
NCoR1 and SMRT play unique roles in thyroid hormone action in vivo.
Molecular and cellular biology null
SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers.
Proceedings of the National Academy of Sciences of the USA, 93, 7567-7571 (1996)
The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT.
Blood null
PloS one, 14(8), e0220717-e0220717 (2019-08-14)
Silencing Mediator of Retinoid and Thyroid Hormone Receptors (SMRT) and the nuclear receptor co-repressor1 (NCoR1) are paralogs and regulate nuclear receptor (NR) function through the recruitment of a multiprotein complex that includes histone deacetylase activity. Previous genetic strategies which deleted
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