06-342
Anti-JAK3 Antibody
serum, Upstate®
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
Species reactivity:
mouse
Citations:
36
Technique(s):
western blot: suitable
Uniprot accession no.:
产品名称
Anti-JAK3 Antibody, serum, Upstate®
biological source
rabbit
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Jak3(16453)
Analysis Note
routinely evaluated by immunoblot on lysate from a mouse cytotoxic T lymphocyte cell line (CTLL)
Application
Anti-JAK3 Antibody is an antibody against JAK3 for use in WB.
Biochem/physiol Actions
: Recognizes murine JAK3, Mr 125kDa and JAK3 degradation products, Mr 95-120kDa. The antiserum shows very poor immunoreactivity for human JAK3. No immunoreaction was noted with immuno-precipitated mouse JAK1 and JAK2
This antibody has been tested on several human cell lines including A431, Hela, Jurkat, and HEK293 cells. The antiserum shows very poor immunoreactivity for human JAK3
General description
125 kDa
Immunogen
peptide corresponding to residues 934-952 (RDELCVAGAQLYACQDPAI) of murine JAK3. The immunizing peptide sequence shares 16/19 amino acids with rat JAK3, but contains an amino acid insertion, which may block cross-reactivity. The immunizing peptide shares 12/19 amino acids with human JAK3.
Physical form
antiserum containing 0.05% sodium azide
Preparation Note
2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery, centrifuge the original vial after thawing and prior to removing the cap.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
R L Palmer-Crocker et al.
The Journal of clinical investigation, 98(3), 604-609 (1996-08-01)
IL-4 and IL-13 each act on human endothelial cells (ECs) to induce expression of vascular cell adhesion molecule-1. On hematopoietic cells. IL-4 responses may be mediated either through a pathway involving gc, the common signaling subunit of the IL-2, IL-4
Ruiqing Xiao et al.
Nature communications, 13(1), 4661-4661 (2022-08-10)
β-Glucans are of significant interest due to their potent antitumor and immunomodulatory activities. Nevertheless, the difficulty in purification, structural heterogenicity, and limited solubility impede the development of structure-property relationships and translation to therapeutic applications. Here, we report the synthesis of
Jak1 expression is required for mediating interleukin-4-induced tyrosine phosphorylation of insulin receptor substrate and Stat6 signaling molecules.
Chen, X H, et al.
The Journal of Biological Chemistry, 272, 6556-6560 (1997)
Differential requirement of the cytoplasmic subregions of gamma c chain in T cell development and function.
Tsujino, S; Di Santo, JP; Takaoka, A; McKernan, TL; Noguchi, S; Taya, C; Yonekawa et al.
Proceedings of the National Academy of Sciences of the USA null
A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit
Molden, J., et al
The Journal of Biological Chemistry, 272, 19625-19631 (1997)
相关内容
The Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway plays an important role in cell proliferation, cell differentiation, cell migration, and cell death. It is the principal signaling mechanism for a variety of cytokines and growth factors. Constitutive activation or dysregulation of JAK/STAT signaling can result in inflammatory disease, erythrocytosis, gigantism, and leukemia.
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