产品名称
抗-c-Jun抗体, serum, Upstate®
biological source
rabbit
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, avian, mouse
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... JUN(3725)
mouse ... Jun(16476)
Analysis Note
对照
阳性抗原对照:目录# 12-303,Jurkat细胞裂解液。
阳性抗原对照:目录# 12-303,Jurkat细胞裂解液。
已通过免疫印迹对人A431细胞或Jurkat细胞裂解液的RIPA裂解液进行了常规评估
Application
用抗c-Jun兔多克隆抗血清(目录号06-225)检测c-Jun(又称转录因子AP-1),已被证明可用于免疫细胞化学,免疫沉淀和蛋白质印迹。
研究子类别
转录因子
转录因子
研究类别
表观遗传学&核功能
表观遗传学&核功能
Biochem/physiol Actions
c-Jun
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
35-39 kDa
c-Jun是转录因子AP-1的一部分,可结合并激活TRE/AP-1元件上的转录,并且似乎是SAPK/JNK信号通路的主要下游靶标。c-Jun的转录活性受Ser63和Ser73的磷酸化的调节。胞外信号(包括生长因子、转化癌蛋白和紫外线照射)刺激c-Jun在Ser63/73处的磷酸化并激活c-Jun依赖性转录。Ser63/73的突变使c-Jun对有丝分裂和应激诱导的
信号通路无反应。MAP激酶的同系物,SAPK/JNK,与c-Jun的N端结合,并在Ser63/73处磷酸化c-Jun。此外,激活c-Jun的信号同样也刺激SAPK/JNK的活性。
信号通路无反应。MAP激酶的同系物,SAPK/JNK,与c-Jun的N端结合,并在Ser63/73处磷酸化c-Jun。此外,激活c-Jun的信号同样也刺激SAPK/JNK的活性。
Immunogen
含有禽c-Jun DNA结合域的Trp E融合蛋白
Other Notes
替代:04-210
Physical form
全兔抗血清,含0.05%叠氮化钠
抗血清
Preparation Note
在-20°C下可保存2年
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
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The Journal of Biological Chemistry null
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Myristylation alters DNA-binding activity and transactivation of FBR (gag-fos) protein
Kamata, N., et al
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