特异性
Na+/K+ ATPase α-3
免疫原
Fusion protein derived the alpha 3 subunit containing residues 320-514
应用
Anti-Na+/K+ ATPase α-3 Antibody detects level of Na+/K+ ATPase α-3 & has been published & validated for use in IH & WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Ion Channels & Transporters
Ion Channels & Transporters
质量
routinely evaluated by immunoblot on brain microsomal preparations
目标描述
112kDa
外形
0.1M Tris-HCl, pH 7.2, containing 0.02% sodium azide
Format: Purified
储存及稳定性
2 years at -20°C
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial
法规信息
新产品
D Romanovsky et al.
Neuroscience, 310, 342-353 (2015-09-20)
Ambulatory instability and falls are a major source of morbidity in the elderly. Age-related loss of tendon reflexes is a major contributing factor to this morbidity, and deterioration of the afferent limb of the stretch reflex is a potential contributing
Namrata Madan et al.
American journal of physiology. Cell physiology, 312(3), C222-C232 (2016-12-03)
The Na/K-ATPase α1 polypeptide supports both ion-pumping and signaling functions. The Na/K-ATPase α3 polypeptide differs from α1 in both its primary structure and its tissue distribution. The expression of α3 seems particularly important in neurons, and recent clinical evidence supports
Toke Jost Isaksen et al.
PLoS genetics, 13(5), e1006763-e1006763 (2017-05-05)
Mutations in the neuron-specific α3 isoform of the Na+/K+-ATPase are found in patients suffering from Rapid onset Dystonia Parkinsonism and Alternating Hemiplegia of Childhood, two closely related movement disorders. We show that mice harboring a heterozygous hot spot disease mutation
Thomas Hellesøe Holm et al.
Scientific reports, 6, 31972-31972 (2016-08-24)
The Na(+)/K(+)-ATPases maintain Na(+) and K(+) electrochemical gradients across the plasma membrane, a prerequisite for electrical excitability and secondary transport in neurons. Autosomal dominant mutations in the human ATP1A3 gene encoding the neuron-specific Na(+)/K(+)-ATPase α3 isoform cause different neurological diseases
Steven J Clapcote et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(33), 14085-14090 (2009-08-12)
In a mouse mutagenesis screen, we isolated a mutant, Myshkin (Myk), with autosomal dominant complex partial and secondarily generalized seizures, a greatly reduced threshold for hippocampal seizures in vitro, posttetanic hyperexcitability of the CA3-CA1 hippocampal pathway, and neuronal degeneration in
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