产品名称
Anti-Parkin Antibody, clone PRK8, ascites fluid, clone PRK8, Upstate®
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
PRK8, monoclonal
species reactivity
human, mouse
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PARK2(5071)
Analysis Note
routinely evaluated by immunoblot on RIPA lysates from HEK293 cells
Application
Anti-Parkin Antibody, clone PRK8 detects level of Parkin & has been published & validated for use in IP, WB, IC, IH.
Biochem/physiol Actions
Parkin
General description
52kDa May be observed as a doublet at 52 and 46kDa
Immunogen
Full length recombinant human Parkin. Epitope has been mapped to the second ring domain (aa 399-465)
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
Nobutaka Hattori et al.
Lancet (London, England), 364(9435), 722-724 (2004-08-25)
The cause and pathogenesis of Parkinson's disease remain unknown; mitochondrial dysfunction, oxidative damage, environmental factors, and genetic predisposition might all be involved. Identification of the causative genes for familial Parkinson's diseases allow study of the pathogenesis of the disease at
Are ubiquitination pathways central to Parkinson's disease?
Giasson, Benoit I and Lee, Virginia M-Y
Cell, 114, 1-8 (2003)
Molecular pathways of neurodegeneration in Parkinson's disease.
Dawson, Ted M and Dawson, Valina L
Science (New York, N.Y.), 302, 819-822 (2003)
Keiji Tanaka et al.
Biochimica et biophysica acta, 1695(1-3), 235-247 (2004-12-02)
The ubiquitin-proteasome system (UPS) is important for intracellular proteolysis, and is responsible for a diverse array of biologically important cellular processes, such as cell-cycle progression, signaling cascades and developmental programs. This system is also involved in the protein quality control
Genotype-phenotype correlation: familial Parkinson disease.
Mori, Hideo, et al.
Neuropathology : Official Journal of the Japanese Society of Neuropathology, 23, 90-94 (2003)
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