05-858R
Anti-Histone H4 Antibody, pan, clone 62-10C-2, rabbit monoclonal
clone 62-10C-2, from rabbit
别名:
H4, Histone H4, H4 histone family, member A, histone 1, H4a, histone cluster 1, H4a
产品名称
Anti-Histone H4 Antibody, pan, clone 62-10C-2, rabbit monoclonal, clone 62-10C-2, from rabbit
isotype
IgG
biological source
rabbit
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
62-10C-2, monoclonal
species reactivity
human
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... H4C1(8359)
Analysis Note
Evaluated by Western Blot in HeLa acid extracts.
Western Blot Analysis: 0.1 µg/ml of this antibody detected histone H4 in 10 µg of HeLa cell lysate.
Western Blot Analysis: 0.1 µg/ml of this antibody detected histone H4 in 10 µg of HeLa cell lysate.
Application
Use Anti-Histone H4 Antibody, pan, clone 62-10C-2 (Rabbit Monoclonal Antibody) validated in WB to detect Histone H4 also known as Histone H4.
Biochem/physiol Actions
Broad species cross-reactivity expected based on 100% sequence homology to multiple species.
General description
Histone H4 is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N terminal tail H4 is involved with the structure of the nucleosomes of the ′beads on a string′ structure.
10 kDa Observed
Immunogen
Epitope: Epitope mapped to residues 25-28.
KLH-conjugated, synthetic peptide corresponding to amino acids 17-28 of Histone H4.
Physical form
Format: Purified
Purified Rabbit Monoclonal IgG Supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl), containing 40% glycerol with 0.05% sodium azide
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Manti Guha et al.
PloS one, 13(11), e0206897-e0206897 (2018-11-15)
Telomeres protect against chromosomal damage. Accelerated telomere loss has been associated with premature aging syndromes such as Werner's syndrome and Dyskeratosis Congenita, while, progressive telomere loss activates a DNA damage response leading to chromosomal instability, typically observed in cancer cells
Sama F Sleiman et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(43), 14328-14337 (2014-10-24)
Histone deacetylase (HDAC) inhibition improves function and extends survival in rodent models of a host of neurological conditions, including stroke, and neurodegenerative diseases. Our understanding, however, of the contribution of individual HDAC isoforms to neuronal death is limited. In this
Saravanan S Karuppagounder et al.
Science translational medicine, 8(328), 328ra29-328ra29 (2016-03-05)
Disability or death due to intracerebral hemorrhage (ICH) is attributed to blood lysis, liberation of iron, and consequent oxidative stress. Iron chelators bind to free iron and prevent neuronal death induced by oxidative stress and disability due to ICH, but
Benjamin E L Lauffer et al.
The Journal of biological chemistry, 288(37), 26926-26943 (2013-07-31)
Histone deacetylases (HDACs) are critical in the control of gene expression, and dysregulation of their activity has been implicated in a broad range of diseases, including cancer, cardiovascular, and neurological diseases. HDAC inhibitors (HDACi) employing different zinc chelating functionalities such
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