05-831-I
Anti-Beta (β)-Amyloid antibody
mouse monoclonal, 12F4
别名:
Amyloid beta A4 protein, ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II
产品名称
β淀粉样蛋白（ABeta）x-42抗体，克隆12F4, clone 12F4, from mouse
biological source
mouse
antibody form
purified antibody
antibody product type
primary antibodies
clone
12F4, monoclonal
species reactivity
human
technique(s)
ELISA: suitable
immunohistochemistry: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... APP(351)
Analysis Note
对照
人阿尔茨海默病脑组织
人阿尔茨海默病脑组织
通过免疫组化对人阿尔茨海默氏病脑组织进行了评估。
免疫组化分析：该抗体的1:2,000稀释液在人阿尔茨海默病脑组织中检测到β淀粉样蛋白（Abeta）x-42。
免疫组化分析：该抗体的1:2,000稀释液在人阿尔茨海默病脑组织中检测到β淀粉样蛋白（Abeta）x-42。
Application
β淀粉样蛋白（ABeta）x-42抗体（克隆12F4）是一种靶向β淀粉样蛋白（ABeta）x-42的抗体，经验证可用于IHC & ELISA。
免疫组化分析：代表性批次的1:500稀释液在人脑桥/中脑组织中检测到β淀粉样蛋白（ABeta）x-42。
ELISA分析：代表性批次检测到β淀粉样蛋白（ABeta）x-42，但显示β淀粉样蛋白（ABeta）x-42信号缺失。
蛋白印迹分析：代表性批次的1:1,000稀释液在WB中检测到β淀粉样蛋白（ABeta）x-42，但显示x-40而非x-43信号缺失（西奈山医学院J. Buxbaum 教授）。
ELISA分析：代表性批次检测到β淀粉样蛋白（ABeta）x-42，但显示β淀粉样蛋白（ABeta）x-42信号缺失。
蛋白印迹分析：代表性批次的1:1,000稀释液在WB中检测到β淀粉样蛋白（ABeta）x-42，但显示x-40而非x-43信号缺失（西奈山医学院J. Buxbaum 教授）。
Biochem/physiol Actions
该抗体可检测β淀粉样蛋白（ABeta）x-42，但不与β淀粉样蛋白（ABeta）x-40或β淀粉样蛋白（ABeta）x-43交叉反应。
General description
在阿尔茨海默病（AD）中，引起记忆和认知丧失的最重要和最初始的步骤之一涉及淀粉样蛋白前体蛋白（APP，21号染色体）的蛋白水解裂解，释放短的40、42 & 43氨基酸肽（β淀粉样蛋白1-40、1-42和1-43）。β-淀粉样蛋白的聚合和随后的神经元沉积（淀粉样蛋白）导致参与记忆和认知的神经元变性。
计算分子量为4 kDa
Immunogen
KLH偶联线性肽，对应于人β淀粉样蛋白（ABeta）x-42。
Other Notes
替代：05-831
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
形式：纯化
未找到合适的产品？
试试我们的产品选型工具.
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Mariah Beaver et al.
Epigenetics, 1-22 (2021-08-10)
Disruption of histone acetylation-mediated gene control is a critical step in Alzheimer's Disease (AD), yet chromatin analysis of antagonistic histone acetyltransferases (HATs) and histone deacetylases (HDACs) causing these alterations remains uncharacterized. We report the first Tip60 HAT versus HDAC2 chromatin
Yasuhisa Ano et al.
Aging, 11(10), 2949-2967 (2019-05-24)
The rapid growth in aging populations has made prevention of age-related memory decline and dementia a high priority. Several epidemiological and clinical studies have concluded that fermented dairy products can help prevent cognitive decline; furthermore, intake of Camembert cheese prevents
Haolin Zhang et al.
Molecular and cellular neurosciences, 109, 103570-103570 (2020-11-08)
Alzheimer's disease (AD) is an age-related neurodegenerative disorder hallmarked by amyloid-β (Aβ) plaque accumulation, neuronal cell death, and cognitive deficits that worsen during disease progression. Histone acetylation dysregulation, caused by an imbalance between reduced histone acetyltransferases (HAT) Tip60 and increased
Raul O Freitas et al.
Cells, 10(10) (2021-10-24)
Alzheimer's disease (AD) accounts for about 70% of neurodegenerative diseases and is a cause of cognitive decline and death for one-third of seniors. AD is currently underdiagnosed, and it cannot be effectively prevented. Aggregation of amyloid-β (Aβ) proteins has been
Song Cao et al.
Journal of neuroinflammation, 18(1), 10-10 (2021-01-08)
The role of microglia in Alzheimer's disease (AD) pathogenesis is becoming increasingly important, as activation of these cell types likely contributes to both pathological and protective processes associated with all phases of the disease. During early AD pathogenesis, one of
相关内容
Alzheimer’s Disease: Amyloid Cascade and Beyond Product Focus
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持