一般描述
在阿尔茨海默病（AD）中，引起记忆和认知丧失的最重要和最初始的步骤之一涉及淀粉样蛋白前体蛋白（APP，21号染色体）的蛋白水解裂解，释放短的40、42 & 43氨基酸肽（β淀粉样蛋白1-40、1-42和1-43）。β-淀粉样蛋白的聚合和随后的神经元沉积（淀粉样蛋白）导致参与记忆和认知的神经元变性。
特异性
该抗体可检测β淀粉样蛋白（ABeta）x-42，但不与β淀粉样蛋白（ABeta）x-40或β淀粉样蛋白（ABeta）x-43交叉反应。
免疫原
KLH偶联线性肽，对应于人β淀粉样蛋白（ABeta）x-42。
应用
β淀粉样蛋白（ABeta）x-42抗体（克隆12F4）是一种靶向β淀粉样蛋白（ABeta）x-42的抗体，经验证可用于IHC & ELISA。
免疫组化分析：代表性批次的1:500稀释液在人脑桥/中脑组织中检测到β淀粉样蛋白（ABeta）x-42。
ELISA分析：代表性批次检测到β淀粉样蛋白（ABeta）x-42，但显示β淀粉样蛋白（ABeta）x-42信号缺失。
蛋白印迹分析：代表性批次的1:1,000稀释液在WB中检测到β淀粉样蛋白（ABeta）x-42，但显示x-40而非x-43信号缺失（西奈山医学院J. Buxbaum 教授）。
ELISA分析：代表性批次检测到β淀粉样蛋白（ABeta）x-42，但显示β淀粉样蛋白（ABeta）x-42信号缺失。
蛋白印迹分析：代表性批次的1:1,000稀释液在WB中检测到β淀粉样蛋白（ABeta）x-42，但显示x-40而非x-43信号缺失（西奈山医学院J. Buxbaum 教授）。
质量
通过免疫组化对人阿尔茨海默氏病脑组织进行了评估。
免疫组化分析：该抗体的1:2,000稀释液在人阿尔茨海默病脑组织中检测到β淀粉样蛋白（Abeta）x-42。
免疫组化分析：该抗体的1:2,000稀释液在人阿尔茨海默病脑组织中检测到β淀粉样蛋白（Abeta）x-42。
目标描述
计算分子量为4 kDa
联系
替代：05-831
外形
形式：纯化
分析说明
对照
人阿尔茨海默病脑组织
人阿尔茨海默病脑组织
其他说明
浓度：请参考批次特异性浓缩物的检验报告。
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WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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