05-829-AF555
Anti-α-Tubulin Antibody, clone DM1A, Alexa Fluor™ 555 Conjugate
clone DM1A, from mouse, ALEXA FLUOR™ 555
别名:
Tubulin alpha-1 chain, Alpha-tubulin, Alpha-1 tubulin
产品名称
Anti-α-Tubulin Antibody, clone DM1A, Alexa Fluor™ 555 Conjugate, clone DM1A, from mouse, ALEXA FLUOR™ 555
biological source
mouse
conjugate
ALEXA FLUOR™ 555
antibody form
purified antibody
antibody product type
primary antibodies
clone
DM1A, monoclonal
species reactivity
guinea pig, gerbil, mouse, bovine, avian, human, rat, porcine
technique(s)
immunocytochemistry: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
target post-translational modification
unmodified
Quality Level
Analysis Note
Evaluated by Immunocytochemistry in A431 cells.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected α-tubulin in A431 cells.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected α-tubulin in A431 cells.
Application
Research Category
Cell Structure
Cell Structure
Research Sub Category
Cytoskeleton
Cytoskeleton
The unconjugated antibody (Cat. No. 05-829) is shown to be suitable also for immunocytochemistry, immunofluorescence, and Western blotting applications.
This Anti-α-Tubulin Antibody, clone DM1A, Alexa Fluor™ 555 Conjugate is validated for use in Immunocytochemistry for the detection of α-Tubulin.
Biochem/physiol Actions
Clone DM1A recognizes α-Tubulin, MW 50-60 kDa. The epitope recognized by this antibody has been mapped to the C-terminal 25 amino acids (AALEKDYEEVGVDSVEGEGEEEGEE).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Tubulin alpha-1 chain (UniProt P02552) is encoded by the TUBA1C (also known as TUBA1) gene (Gene ID 429035) in Gallus gallus (Chicken) species. Microtubules are cytoskeletal filaments composed of of alpha-/beta-tubulin heterodimers that self-assemble head-to-tail to form protofilaments and laterally to form a hollow tubes. Various post-translational modifications (PTMs), including acetylation, polyglutamylation, polyglycylation, detyrosination, phosphorylation, and palmitoylation, can regulate the polymerization properties of tubulins and/or their interactions with microtubule associated proteins (MAPs) and motor proteins.
~50 kDa observed.
Immunogen
Epitope: C-terminal 25 amino acids.
Purified chicken brain α-tubulin.
Other Notes
Concentration: Please refer to lot specific datasheet.
Physical form
Protein G purified.
Purified mouse monoclonal IgG1 antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Priya Mondal et al.
Scientific reports, 14(1), 15912-15912 (2024-07-11)
Pancreatic adenocarcinoma is one of the most aggressive and lethal forms of cancer. Chemotherapy is the primary treatment for pancreatic cancer, but resistance to the drugs used remains a major challenge. A genome-wide CRISPR interference and knockout screen in the
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