产品名称
抗二甲基组蛋白H3（Arg2）抗体，兔单克隆, Upstate®, from rabbit
biological source
rabbit
antibody form
purified antibody
antibody product type
primary antibodies
clone
monoclonal
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
dot blot: suitable
inhibition assay: suitable (peptide)
multiplexing: suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
dimethylation (Arg2)
Quality Level
Gene Information
human ... H3C1(8350)
Analysis Note
对HeLa细胞的酸提取蛋白进行了常规评估
对照
HeLa细胞的酸提取物
HeLa细胞的酸提取物
Application
使用在DB、WB、PIA、Mplex中验证的抗二甲基组蛋白H3（Arg2）抗体（兔单克隆抗体）检测二甲基组蛋白H3（Arg2），也称为H3R2me2、组蛋白H3（二甲基R2）。
General description
组蛋白H3是参与真核细胞染色质结构的五种主要组蛋白之一。H3具有一个主要的球状结构域和一个长N末端的尾巴，其与核糖体核小体′串珠′结构体的结构有关。
组蛋白H3的N末端尾部从球状核小体核心突起，其可能发生几种不同类型的表观遗传修饰，从而影响细胞过程。这些修饰包括甲基或乙酰基与赖氨酸和精氨酸的共价连接，以及丝氨酸或苏氨酸的磷酸化。
组蛋白H3的N末端尾部从球状核小体核心突起，其可能发生几种不同类型的表观遗传修饰，从而影响细胞过程。这些修饰包括甲基或乙酰基与赖氨酸和精氨酸的共价连接，以及丝氨酸或苏氨酸的磷酸化。
17kDa
Immunogen
一种含有序列AdimRTKQ的肽，对应于人组蛋白H3的二甲基-精氨酸2
Physical form
形式：纯化
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
Lessly P Sepulveda-Rincon et al.
Biology of reproduction, 95(6), 123-123 (2016-10-21)
The first lineage specification during mammalian embryo development can be visually distinguished at the blastocyst stage. Two cell lineages are observed on the embryonic-abembryonic axis of the blastocyst: the inner cell mass and the trophectoderm. The timing and mechanisms driving
Zichuan Liu et al.
Developmental biology, 368(2), 304-311 (2012-06-05)
Several research groups have suggested that the embryonic-abembryonic (Em-Ab) axis in the mouse can be predicted by the first cleavage plane of the early embryo. Currently, it is not known whether this early patterning occurs in cloned embryos produced by
Alessandra Di Lorenzo et al.
Nucleic acids research, 42(13), 8297-8309 (2014-06-19)
Protein arginine methyltransferase 6 (PRMT6) is a nuclear enzyme that modifies histone tails. To help elucidate the biological function of PRMT6 in vivo, we generated transgenic mice that ubiquitously express PRMT6 fused to the hormone-binding portion of the estrogen receptor
Sitaram Gayatri et al.
Scientific reports, 6, 28718-28718 (2016-06-25)
Signal transduction in response to stimuli relies on the generation of cascades of posttranslational modifications that promote protein-protein interactions and facilitate the assembly of distinct signaling complexes. Arginine methylation is one such modification, which is catalyzed by a family of
Ayaz Ahmad et al.
PloS one, 6(8), e22664-e22664 (2011-08-20)
Post-translational methylation of arginine residues profoundly affects the structure and functions of protein and, hence, implicated in a myriad of essential cellular processes such as signal transduction, mRNA splicing and transcriptional regulation. Protein arginine methyltransferases (PRMTs), the enzymes catalyzing arginine
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