05-797R
抗-磷酸化-Erk1/2（Thr202/Tyr204，Thr185/Tyr187）抗体，重组克隆AW39R，兔单克隆
clone AW39R, Upstate®, from rabbit
登录查看公司和协议定价
所有图片(1)
别名:
Erk1, Erk2, p44-MAPK, p42-MAPK, MAPK2, PRKM2, p41mapk, PRKM1, p44, ERK2, P42MAPK, ERK, p42, MAPK1, ERT1, ERT2, Mitogen-activated protein kinase, MAP Kinase 2, MAP Kianse 1, MAPK
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41
推荐产品
生物来源
rabbit
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
AW39R, monoclonal
种属反应性
human, mouse, rat
制造商/商品名称
Upstate®
技术
multiplexing: suitable
western blot: suitable
同位素/亚型
IgG
运输
dry ice
靶向翻译后修饰
phosphorylation ((pThr202/pTyr204), (pThr185/pTyr187))
基因信息
human ... MAPK3(5595)
mouse ... Mapk3(26417)
rat ... Mapk3(50689)
一般描述
Erk（细胞外信号相关激酶）是两个高度同源的蛋白质家族，分别称为Erk1（p44，MAPK3）和Erk2（p42，MAPK1），它们都在同一途径中起作用。 这两种蛋白通常统称为Erk1/2或p44/p42 MAP激酶。Erk途径被认为是经典的，经典的MAPK（促分裂原活化蛋白激酶）信号传导途径。它是一种进化上保守的途径，通过促进细胞增殖和防止细胞凋亡来控制并作为关键调节剂来控制生长和存活。Erk参与许多基本细胞过程的控制，包括细胞增殖，存活，分化，凋亡，运动性和代谢。Erk通过受体酪氨酸激酶（RTK）的生长因子刺激，GPCR和/或整联蛋白刺激而激活。这会激活Ras-Raf-MEK-Erk途径，从而导致TxY基序上的Erk1/2（p44/p42）磷酸化/激活（Erk1 & Erk2分别为Thr202/Tyr204和Thr185/Tyr187）。
特异性
仅当Erk 1 & 2在其TxY激活基序上双重磷酸化时才能识别Erk 1 2。
免疫原
一种磷酸化肽，对应于人磷酸化-ERK1/2激活环中pTEpY基序周围的氨基酸，其中Thr和Tyr残基被磷酸化
表位：激活环中的pTEpY
应用
抗磷酸化Erk1/2（Thr202/Tyr204抗体，Thr185/Tyr187），重组克隆AW39R检测磷酸化Erk1/2的水平（Thr202/Tyr204&已发表，&经验证可用于Mplex & WB。
研究子类别
MAP激酶
激酶&磷酸酶
MAP激酶
激酶&磷酸酶
研究类别
信号传导
信号传导
质量
已通过免疫印迹对PDGF处理的NIH/3T3细胞裂解液进行常规评估
目标描述
Erk1 (p44) (~44 kDa) 和Erk2 (p42) (~42 kDa)。
联系
替代：05-797
外形
形式：纯化
蛋白A纯化
蛋白A纯化的免疫球蛋白溶于30％甘油，0.07M Tris-甘氨酸（pH 7.4）、0.105 M NaCl，0.035％叠氮化钠作为防腐剂的溶液中。
储存及稳定性
自收到之日起在-20°C可稳定保存1年。处理建议：收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。分装到微量离心管中，并储存于 -20°C。避免反复冻融循环，以免损坏 IgG 和影响产品性能。
分析说明
对照
PDGF处理的NIH/3T3细胞裂解液
PDGF处理的NIH/3T3细胞裂解液
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Wen-Tsan Chang et al.
Molecules (Basel, Switzerland), 22(5) (2017-05-23)
Hepatocellular carcinoma (HCC) is a leading cancer worldwide. Advanced HCCs are usually resistant to anticancer drugs, causing unsatisfactory chemotherapy outcomes. In this study, we showed that a 4-phenoxyphenol derivative, 4-[4-(4-hydroxyphenoxy)phenoxy]phenol (4-HPPP), exerts an inhibitory activity against two HCC cell lines
Jiamin Cheng et al.
Oncotarget, 7(15), 20597-20611 (2016-03-12)
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death. This high mortality has been commonly attributed to the presence of residual cancer stem cells (CSCs). Meanwhile, MEK1 signaling is regarded as a key molecular in HCC maintenance and
Pao Hsien Huang et al.
Pharmaceutics, 11(8) (2019-08-11)
As is known, many antioxidants from plant extracts have been used as additives in skincare products to prevent skin damage following overexposure to environmental pollutants. 7,3',4'-trihydroxyisoflavone (734THIF), an isoflavone compound, possesses various biological activities, including antioxidant, antityrosinase, photodamage protection, and
Susanna A Jethwa et al.
Journal of cell science, 129(20), 3948-3957 (2016-08-26)
Autotaxin (ATX; also known as ENPP2), the lysophospholipase responsible for generating the lipid receptor agonist lysophosphatidic acid (LPA), is a secreted enzyme. Here we show that, once secreted, ATX can bind to the surface of cell-secreted exosomes. Exosome-bound ATX is
Dhia Azzouz et al.
Cell death discovery, 4, 51-51 (2018-05-08)
NETosis is a unique form of neutrophil death that differs from apoptosis and necrosis. However, whether NETosis and apoptosis can occur simultaneously in the same neutrophil is unknown. In this paper, we show that increasing doses of ultraviolet (UV) irradiation
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门