05-797R
抗-磷酸化-Erk1/2（Thr202/Tyr204，Thr185/Tyr187）抗体，重组克隆AW39R，兔单克隆
clone AW39R, Upstate®, from rabbit
别名:
Erk1, Erk2, p44-MAPK, p42-MAPK, MAPK2, PRKM2, p41mapk, PRKM1, p44, ERK2, P42MAPK, ERK, p42, MAPK1, ERT1, ERT2, Mitogen-activated protein kinase, MAP Kinase 2, MAP Kianse 1, MAPK
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
AW39R, monoclonal
Species reactivity:
human, mouse, rat
Application:
WB, multiplexing
Citations:
46
biological source
rabbit
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
AW39R, monoclonal
species reactivity
human, mouse, rat
manufacturer/tradename
Upstate®
technique(s)
multiplexing: suitable, western blot: suitable
isotype
IgG
shipped in
dry ice
target post-translational modification
phosphorylation ((pThr202/pTyr204), (pThr185/pTyr187))
Gene Information
human ... MAPK3(5595)
mouse ... Mapk3(26417)
rat ... Mapk3(50689)
General description
Erk1 (p44) (~44 kDa) 和Erk2 (p42) (~42 kDa)。
Erk（细胞外信号相关激酶）是两个高度同源的蛋白质家族，分别称为Erk1（p44，MAPK3）和Erk2（p42，MAPK1），它们都在同一途径中起作用。 这两种蛋白通常统称为Erk1/2或p44/p42 MAP激酶。Erk途径被认为是经典的，经典的MAPK（促分裂原活化蛋白激酶）信号传导途径。它是一种进化上保守的途径，通过促进细胞增殖和防止细胞凋亡来控制并作为关键调节剂来控制生长和存活。Erk参与许多基本细胞过程的控制，包括细胞增殖，存活，分化，凋亡，运动性和代谢。Erk通过受体酪氨酸激酶（RTK）的生长因子刺激，GPCR和/或整联蛋白刺激而激活。这会激活Ras-Raf-MEK-Erk途径，从而导致TxY基序上的Erk1/2（p44/p42）磷酸化/激活（Erk1 & Erk2分别为Thr202/Tyr204和Thr185/Tyr187）。
Immunogen
一种磷酸化肽，对应于人磷酸化-ERK1/2激活环中pTEpY基序周围的氨基酸，其中Thr和Tyr残基被磷酸化
表位：激活环中的pTEpY
Application
抗磷酸化Erk1/2（Thr202/Tyr204抗体，Thr185/Tyr187），重组克隆AW39R检测磷酸化Erk1/2的水平（Thr202/Tyr204&已发表，&经验证可用于Mplex & WB。
研究子类别
MAP激酶
激酶&磷酸酶
MAP激酶
激酶&磷酸酶
研究类别
信号传导
信号传导
Biochem/physiol Actions
仅当Erk 1 & 2在其TxY激活基序上双重磷酸化时才能识别Erk 1 2。
Physical form
形式：纯化
蛋白A纯化
蛋白A纯化的免疫球蛋白溶于30％甘油，0.07M Tris-甘氨酸（pH 7.4）、0.105 M NaCl，0.035％叠氮化钠作为防腐剂的溶液中。
Preparation Note
自收到之日起在-20°C可稳定保存1年。处理建议：收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。分装到微量离心管中，并储存于 -20°C。避免反复冻融循环，以免损坏 IgG 和影响产品性能。
Analysis Note
对照
PDGF处理的NIH/3T3细胞裂解液
PDGF处理的NIH/3T3细胞裂解液
已通过免疫印迹对PDGF处理的NIH/3T3细胞裂解液进行常规评估
Other Notes
替代：05-797
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 05-797R | 04053252512162 |