生物来源
mouse
质量水平
抗体形式
affinity purified immunoglobulin
抗体产品类型
primary antibodies
克隆
N4.4, monoclonal
种属反应性
mouse, human
制造商/商品名称
Upstate®
技术
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型
IgG1
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... KMT2A(4297)
一般描述
The acute lymphoblastic leukaemia (ALL)-1 (also known as MLL, HRX, HTRX, and TRX1) gene on human chromosome 11q23 is the site of many locally clustered chromosomal alterations associated with several types of acute leukaemias, including deletions, partial duplications and translocations. Structurally variant proteins derived from the altered gene presumably cause the malignant transformation of early haemopoietic progenitor cells.
特异性
Recognizes N-terminal proteolytic fragment of MLL (MLLN).
免疫原
MBP fusion protein corresponding to residues 161-356 of human mixed lineage leukemia, MLL
应用
Detect MLL/HRX with Anti-MLL/HRX Antibody, N-term., clone N4.4 (Mouse Monoclonal Antibody), that has been shown to work in IP & WB.
质量
routinely evaluated by immunoblot on nuclear extract from K562 cells
目标描述
300 kDa
外形
Format: Purified
Immunoaffinity Purified immunoglobulin in 0.014M phosphate buffer, pH 7.6, 0.175M NaCl, 0.07% sodium azide, and 30% glycerol.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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WGK
WGK 1
Clara Bueno et al.
Cell research, 22(6), 986-1002 (2012-01-04)
The MLL-AF4 fusion gene is a hallmark genomic aberration in high-risk acute lymphoblastic leukemia in infants. Although it is well established that MLL-AF4 arises prenatally during human development, its effects on hematopoietic development in utero remain unexplored. We have created
Anmaar M Abdul-Nabi et al.
PloS one, 5(8), e12464-e12464 (2010-09-02)
Different fusion oncogenes in acute myeloid leukemia (AML) have distinct clinical and laboratory features suggesting different modes of malignant transformation. Here we compare the in vitro effects of representatives of 4 major groups of AML fusion oncogenes on primary human
Jenne M Westberry et al.
Endocrinology, 151(2), 731-740 (2009-12-08)
Estrogens play a critical role in brain development by acting on areas that express estrogen receptors. In the rodent cortex, estrogen receptor alpha (ER alpha) mRNA expression is high early in postnatal development but declines starting at postnatal day (PND)
Stefanie Meier et al.
Cell death & disease, 12(8), 785-785 (2021-08-13)
Pediatric gliomas comprise a broad range of brain tumors derived from glial cells. While high-grade gliomas are often resistant to therapy and associated with a poor outcome, children with low-grade gliomas face a better prognosis. However, the treatment of low-grade
Hairong Huo et al.
Cancer research, 70(21), 8726-8735 (2010-09-24)
The multidrug resistance 1 gene (MDR1) encodes P-glycoprotein (Pgp), a member of the ATP-binding cassette (ABC) transporter family that confers tumor drug resistance by actively effluxing a number of antitumor agents. We had previously shown that MDR1 transcription is regulated
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