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生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
SKB3, monoclonal
种属反应性
rat, human, mouse
制造商/商品名称
Upstate®
技术
western blot: suitable
同位素/亚型
IgG1κ
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... MBP(4155)
mouse ... Mbp(17196)
rat ... Mbp(24547)
特异性
Recognizes MBP.
免疫原
Peptide corresponding to the human myelin basic protein sequence containing amino acid Thr98
应用
Detect MBP using this Anti-MBP Antibody, clone SKB3 validated for use in WB.
Research Category
Signaling
Signaling
Research Sub Category
MAP Kinases
MAP Kinases
质量
routinely evaluated by immunoblot on RIPA lysates from mouse and rat brain tissue preparations
目标描述
18-20 kDa
外形
Protein G Purified
Format: Purified
Protein G Purified immunoglobulin in Immunoaffinity Purified immunoglobulin in 0.02M Phosphate Buffer, 0.25 M NaCl, pH 7.6 with 15 mg/mL BSA containing no preservatives.
储存及稳定性
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
分析说明
Control
Brain tissue
Brain tissue
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
Monica Giannotta et al.
EMBO molecular medicine, 6(2), 239-258 (2014-01-01)
Muscular dystrophies are severe genetic diseases for which no efficacious therapies exist. Experimental clinical treatments include intra-arterial administration of vessel-associated stem cells, called mesoangioblasts (MABs). However, one of the limitations of this approach is the relatively low number of cells
Samantha K Barton et al.
Frontiers in neuroscience, 15, 705306-705306 (2021-09-21)
Pathological hallmarks of amyotrophic lateral sclerosis (ALS), including protein misfolding, are well established in oligodendrocytes. More recently, an RNA trafficking deficit of key myelin proteins has been suggested in oligodendrocytes in ALS but the extent to which this affects myelination
Bangfu Zhu et al.
International journal of molecular sciences, 17(11) (2016-11-24)
The guided migration of neural cells is essential for repair in the central nervous system (CNS). Oligodendrocyte progenitor cells (OPCs) will normally migrate towards an injury site to re-sheath demyelinated axons; however the mechanisms underlying this process are not well
Robert Sparks et al.
The Journal of biological chemistry, 294(41), 14896-14910 (2019-08-16)
The metabolic consequences and sequelae of obesity promote life-threatening morbidities. PKCδI is an important elicitor of inflammation and apoptosis in adipocytes. Here we report increased PKCδI activation via release of its catalytic domain concurrent with increased expression of proinflammatory cytokines
Yuki Miyamoto et al.
Journal of cell science, 120(Pt 24), 4355-4366 (2007-11-29)
Oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes (OLs) in order to form myelin, which is required for the rapid propagation of action potentials in the vertebrate nervous system. In spite of the considerable clinical importance of myelination, little is known
商品
Derivation and characterization of functional human neural stem cell derived oligodendrocyte progenitor cells (OPCs) that efficiently myelinate primary neurons in culture.
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