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Merck
CN
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文件

05-636-AF488

Sigma-Aldrich

抗磷酸化组蛋白H2A.X (Ser139) ，克隆JBW301，Alexa Fluor™ 488 结合抗体

clone JBW301, from mouse, ALEXA FLUOR™ 488

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别名:
Histone H2AX, H2a/x, Histone H2A.X
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

mouse

质量水平

100

偶联物

ALEXA FLUOR™ 488

抗体形式

purified antibody

抗体产品类型

primary antibodies

克隆

JBW301, monoclonal

种属反应性

human

种属反应性（根据同源性预测）

vertebrates (based on 100% sequence homology)

技术

immunocytochemistry: suitable

同位素/亚型

IgG1

NCBI登记号

NP_002096

UniProt登记号

P16104

运输

wet ice

靶向翻译后修饰

phosphorylation (pSer139)

基因信息

human ... H2AX(3014)

一般描述

组蛋白H2A.X是组蛋白H2A的变体，与基因组DNA相似。但是，组蛋白在结构上与H2A家族的其他成员不同，因为它具有一个C末端尾巴，该尾巴包含Ser139残基，该残基响应于双链DNA的断裂而被磷酸化。H2A.X的磷酸化是由ATM/ATR蛋白介导的快速过程。

应用

该抗磷酸化组蛋白H2A.X（Ser139）抗体（克隆JBW301，Alexa Fluor™ 488偶联物）经验证可用于ICC检测磷酸化组蛋白H2A.X（Ser139）。

质量

通过免疫细胞化学在未处理（阴性对照）和星形孢菌素处理的HeLa细胞中进行评估。

免疫细胞化学分析：来自代表性批次的1:100稀释液在星形孢菌素处理的HeLa细胞中检测到磷酸组蛋白H2A.X（Ser139），而在未处理的HeLa细胞中未检测到。

目标描述

计算分子量为17 kDa

其他说明

浓度：请参考批次特异性浓缩物的分析证书。

法律信息

ALEXA FLUOR is a trademark of Life Technologies

WGK

WGK 2

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