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Merck
CN

05-611

抗磷酸化-VASP (Ser239) 抗体，克隆16C2

clone 16C2, Upstate®, from mouse

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
16C2, monoclonal
Species reactivity:
mouse, rat, human
Application:
flow cytometry
immunocytochemistry
western blot
Technique(s):
flow cytometry: suitable
immunocytochemistry: suitable
western blot: suitable
Citations:
18
Uniprot accession no.:
P50552

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产品名称

抗磷酸化-VASP (Ser239) 抗体，克隆16C2, clone 16C2, Upstate®, from mouse

biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

16C2, monoclonal

species reactivity

mouse, rat, human

manufacturer/tradename

Upstate®

technique(s)

flow cytometry: suitable
immunocytochemistry: suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NM_003370

UniProt accession no.

P50552

shipped in

wet ice

target post-translational modification

phosphorylation (pSer239)

Quality Level

100

Gene Information

human ... VASP(7408)

相关类别

Biochem/physiol Actions

磷酸化VASP
基于序列同源性，预计该抗体也会与犬和牛发生交叉反应。

Analysis Note

通过免疫印迹对CTLL细胞的RIPA裂解液进行了常规评估

Application

研究子类别
细胞骨架信号转导
研究类别
信号传导
该抗磷酸化VASP (Ser239)抗体，克隆16C2经过验证可用在FC、WB、IC中，检测磷酸化VASP (Ser239)。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

50kDa

Immunogen

磷酸化肽，对应于人磷酸化VASP（RKV[pS]KQE）的236-242位氨基酸

Physical form

100 µg来自无血清细胞培养上清液的小鼠IgG1，通过亲硫吸附和尺寸排阻色谱法纯化。 从1 ml PBS、0.1%叠氮化钠、PEG和蔗糖中冻干。 冻干粉末。用100 µL H2O复溶（15 min，RT），使最终浓度为1 mg/mL。 储存于 -20°C。
亲硫吸附色谱
形式：纯化

Preparation Note

在-20°C下可保存2年

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

10 - Combustible liquids

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Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells.
Bergandi, L; Silvagno, F; Russo, I; Riganti, C; Anfossi, G; Aldieri, E; Ghigo, D; Trovati et al.
Arteriosclerosis, Thrombosis, and Vascular Biology null
I Kishimoto et al.
Journal of neuroendocrinology, 20(11), 1213-1223 (2008-08-30)
Cyclic GMP (cGMP) is known to play important roles for neuronal development and neurite pathfinding. However, the regulatory mechanism that governs the synthesis of cGMP in the nervous system is not well defined. In the present study, we examined the
A Mülsch et al.
Circulation, 103(17), 2188-2194 (2001-05-23)
Chronic in vivo treatment with nitroglycerin (NTG) induces tolerance to nitrates and cross-tolerance to nitrovasodilators and endothelium-derived nitric oxide (NO). We previously identified increased vascular superoxide formation and reduced NO bioavailability as one causal mechanism. It is still controversial whether
Susan L Lindsay et al.
Journal of cell science, 120(Pt 17), 3011-3021 (2007-08-09)
The initial step in directed cell movement is lamellipodial protrusion, an action driven by actin polymerization. Enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) family proteins are key regulators of this actin polymerization and can control lamellipodial protrusion rate. Ena/VASP proteins are substrates for modification
Olena Rudyk et al.
Circulation, 126(3), 287-295 (2012-06-12)
Although nitroglycerin has remained in clinical use since 1879, the mechanism by which it relaxes blood vessels to lower blood pressure remains incompletely understood. Nitroglycerin undergoes metabolism that generates several reaction products, including oxidants, and this bioactivation process is essential
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