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生物来源
mouse
质量水平
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
monoclonal
种属反应性
rat, human
制造商/商品名称
Upstate®
技术
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型
IgG
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... FRS2(10818)
特异性
FRS2/SNT-1 in unstimulated cells and phosphorylated FRS2/SNT-1 in NGF-stimulated cells
免疫原
Peptide corresponding to residues 283-297 of human FRS2/SNT-1
应用
Detect FRS2/SNT-1 using this Anti-FRS2/SNT-1 Antibody validated for use in IP & WB.
Research Category
Signaling
Signaling
Research Sub Category
Developmental Signaling
Developmental Signaling
质量
routinely evaluated by immunoprecipitating FRS2/SNT-1 from NGF-stimulated and unstimulated rat PC-12 RIPA cell lysates, subsequently immunoblotted with the same antibody.
目标描述
non-phosphorylated (68kDa) and phosphorylated (83kDa)
外形
Protein G Chromatography
0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide containing 30% glycerol
Format: Purified
储存及稳定性
2 years at -20°C
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
Human fibroblast growth factor receptor 1-IIIb is a functional fibroblast growth factor receptor expressed in the pancreas and involved in proliferation and movement of pancreatic ductal cells.
Zhanbing Liu, Toshiyuki Ishiwata, Shaxia Zhou, Susanne Maier, Doris Henne-Bruns et al.
Pancreas null
S O Meakin et al.
The Journal of biological chemistry, 274(14), 9861-9870 (1999-03-27)
We have isolated a human cDNA for the signaling adapter molecule FRS-2/suc1-associated neurotrophic factor target and shown that it is tyrosine-phosphorylated in response to nerve growth factor (NGF) stimulation. Importantly, we demonstrate that the phosphotyrosine binding domain of FRS-2 directly
Vito Guagnano et al.
Cancer discovery, 2(12), 1118-1133 (2012-09-25)
Patient stratification biomarkers that enable the translation of cancer genetic knowledge into clinical use are essential for the successful and rapid development of emerging targeted anticancer therapeutics. Here, we describe the identification of patient stratification biomarkers for NVP-BGJ398, a novel
H Xu et al.
The Journal of biological chemistry, 273(29), 17987-17990 (1998-07-11)
Fibroblast growth factors (FGFs) stimulate tyrosine phosphorylation of a membrane-anchored adapter protein, FRS2/SNT-1, promoting its association with Shp-2 tyrosine phosphatase and upstream activators of Ras. Using the yeast two-hybrid protein-protein interaction assay, we show that FRS2/SNT-1 and a newly isolated
Agnes W Wong et al.
Journal of neurochemistry, 106(4), 1964-1976 (2008-07-16)
The neurotrophin receptor homolog (NRH2) is closely related to the p75 neurotrophin receptor (p75NTR); however, its function and role in neurotrophin signaling are unclear. NRH2 does not bind to nerve growth factor (NGF), however, is able to form a receptor
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