05-382
Na+/K+ ATPase β-1抗体，克隆C464.8
clone C464.8, Upstate®, from mouse
别名:
Anti-AHC2, Anti-ATP1A1, Anti-CAPOS, Anti-DEE99, Anti-DYT12, Anti-RDP
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
C464.8, monoclonal
Application:
immunohistochemistry
western blot
western blot
Species reactivity:
rabbit, bovine, canine, human, rat
Citations:
39
Technique(s):
immunohistochemistry: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
Na+/K+ ATPase β-1抗体，克隆C464.8, clone C464.8, Upstate®, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
C464.8, monoclonal
species reactivity
rabbit, bovine, canine, human, rat
manufacturer/tradename
Upstate®
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ATP1A3(478)
Application
研究子类别
离子通道 & 转运蛋白
离子通道 & 转运蛋白
研究类别
神经科学
神经科学
这种Na+/K+ ATPase β-1抗体（克隆C464.8）经验证可用于IH、WB检测Na+/K+ ATPase β-1。
Analysis Note
对照
在脑、心脏和肾脏等大多数组织中均有表达
在脑、心脏和肾脏等大多数组织中均有表达
通过免疫印迹法对大鼠脑、大鼠心脏或大鼠肾脏微粒体制备物进行了常规评估
Biochem/physiol Actions
可识别Na+/K+的β-1亚基同工型。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
克隆C464.8又称克隆8A
由于糖基化作用，出现表观分子量48-55kDa的宽条带
Immunogen
从兔肾髓质膜部分分离的纯化的Na+/K+ATPase。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
形式：纯化
蛋白G纯化
蛋白G纯化的免疫球蛋白，溶于含0.05％叠氮化钠的PBS中，然后添加甘油至30％
Preparation Note
自收到之日起在-20°C可稳定保存2年。避免反复冻融。为了最大程度地回收产品，在融化后和取下盖子之前，将原始小瓶进行离心。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Analysis of subunit assembly of the Na-K-ATPase.
Fambrough, D M, et al.
The American Journal of Physiology, 266, C579-C589 (1994)
Aude Belliard et al.
Physiological reports, 4(19) (2016-10-06)
Cardiac glycosides (CG) are traditionally known as positive cardiac inotropes that inhibit Na+/K+-ATPase-dependent ion transport. CG also trigger-specific signaling pathways through the cardiac Na+/K+-ATPase, with beneficial effects in ischemia/reperfusion (I/R) injury (e.g., ouabain preconditioning, known as OPC) and hypertrophy. Our
J Codina et al.
The Journal of biological chemistry, 273(14), 7894-7899 (1998-05-09)
Previous experiments from our laboratory (Codina, J., Kone, B. C., Delmas-Mata, J. T., and DuBose, T. D., Jr. (1996) J. Biol. Chem. 271, 29759-29763) demonstrated that the alpha-subunit of the colonic H+, K+-ATPase (HKalpha2) requires coexpression with a beta-subunit to
Fangfang Lai et al.
The Journal of biological chemistry, 288(19), 13295-13304 (2013-03-28)
It has not been possible to study the pumping and signaling functions of Na/K-ATPase independently in live cells. Both cell-free and cell-based assays indicate that the A420P mutation abolishes the Src regulatory function of Na/K-ATPase. A420P mutant has normal pumping
Man Liang et al.
The Journal of biological chemistry, 282(14), 10585-10593 (2007-02-14)
Recent studies have ascribed many non-pumping functions to the Na/K-ATPase. Here, we present experimental evidence demonstrating that over half of the plasma membrane Na/K-ATPase in LLC-PK1 cells is performing cellular functions other than ion pumping. This "non-pumping" pool of Na/K-ATPase
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