05-23-3801
Endothelin 3, Human and Rat
Attenuates thrombin-evoked aggregation of human platelets.
别名:
Endothelin 3, Human and Rat, ET-3, CTCFTYKDKECVYYCHLDIIW
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关于此项目
经验公式（希尔记法）:
C121H168N26O33S4
化学文摘社编号:
分子量:
2643.04
UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
InChI
1S/C121H168N26O33S4/c1-11-62(7)97(117(175)139-89(121(179)180)49-70-53-126-77-25-17-16-24-75(70)77)145-118(176)98(63(8)12-2)144-112(170)88(52-95(157)158)136-105(163)81(44-60(3)4)131-109(167)86(50-71-54-125-59-127-71)134-113(171)90-56-182-181-55-76(124)101(
InChI key
OQGZWNZGVYLIFX-XKIQDWPYSA-N
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated
solubility
5% acetic acid: 0.5 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
Attenuates thrombin-evoked aggregation of human platelets. A potent stimulator of interleukin-6 production by endothelial cell lines. Reported to activate phospholipase C in fibroblasts expressing ETA receptors.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Stimulator of interleukin-6 production by endothelial cell lines
Stimulator of interleukin-6 production by endothelial cell lines
Product does not compete with ATP.
Reversible: no
Packaging
Yes
Physical form
Supplied as a trifluoroacetate salt. Sold on the basis of peptide content.
Preparation Note
Dissolve peptide initially at 8 mg/ml in 80% cold acetic acid, then dilute with cold water to 5% acetic acid and 0.5 mg/ml peptide.
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Other Notes
Gresser, O., et al. 1996. Biochem. Biophys. Res. Commun.224, 169.
Astarie-Dequeker, C., et al. 1995. Br. J. Pharmacol. 114, 524.
Xin, X., et al. 1995. Endocrinology 136, 132.
Brunner, F., et al. 1992. J. Mol. Cell. Cardiol.24, 1291.
Lamers, J.M., et al. 1992. Mol. Cell. Biochem. 116, 59.
Astarie-Dequeker, C., et al. 1995. Br. J. Pharmacol. 114, 524.
Xin, X., et al. 1995. Endocrinology 136, 132.
Brunner, F., et al. 1992. J. Mol. Cell. Cardiol.24, 1291.
Lamers, J.M., et al. 1992. Mol. Cell. Biochem. 116, 59.
H-Cys¹-Thr-Cys³-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Tyr-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
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