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Merck
CN
所有图片(1)

主要文件

05-23-1200

Sigma-Aldrich

Neurotensin

Potent hypothalamic peptide neurotransmitter.

别名:

Neurotensin, NT, NTS, Pyr-LYENKPRRPYIL

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About This Item

经验公式（希尔记法）:
C78H121N21O20
CAS号:
39379-15-2
分子量:
1672.92
MDL编号:
MFCD00080064
UNSPSC代码:
12352202
NACRES:
NA.77

质量水平

100

方案

≥97% (HPLC)

表单

lyophilized solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)

颜色

white to off-white

溶解性

5% acetic acid: 1 mg/mL

运输

ambient

储存温度

−20°C

SMILES字符串

N3(C(CCC3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)N4C(CCC4)C(=O)NC(Cc5ccc(cc5)O)C(=O)NC(C(CC)C)C(=O)NC(CC(C)C)C(=O)O)C(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CC2)CC(C)C)Cc1ccc(cc1)O)CCC(=O)O)CC(=O)N)CCCCN

InChI

1S/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)

InChI key

PCJGZPGTCUMMOT-UHFFFAOYSA-N

一般描述

Neurotensin (NT), a 13-amino acid peptide neurotransmitter encoded by the NTS gene. NT is located in the gastrointestinal tract and heterogeneously distributed in the mammalian central nervous system, and has many neurotransmitter-like characteristics. It influences various central and peripheral functions by interacting with three neurotensin receptors. It is linked to the modulation of dopaminergic systems and in the induction of changes in behavior, muscle relaxation, nociception, and hypothermia, as well as appetite, learning, memory, and fat metabolism. Moreover, it is a modulator of noradrenergic activity. It also acts as an endogenous anti-psychotic compound and lowers blood pressure, increases vascular permeability, and increases plasma levels of glucagon, glucose, growth hormone, and prolactin in rats. Additionally, it regulates the release of pituitary hormones from the brain and insulin, glucagon, and somatostatin from the gut.

生化/生理作用

Cell permeable: no
Primary Target
Modulator of noradrenergic activity
Product does not compete with ATP.
Reversible: no

包装

Yes

警告

Toxicity: Standard Handling (A)

序列

Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH

其他说明

Kinkead, B., et al. 1999. Biol. Psychiatr.46, 340.
Tyler, B.M., et al. 1998. Brain Res. 792, 246.
Tsuda, K., and Masuyuma, Y. 1993. Am. J. Hypertens. 6, 473.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Napatsorn Saiyasit et al.
Neuropeptides, 72, 12-22 (2018-10-04)
Neurotensin is an endogenous tridecapeptide that can be found in both central and peripheral nervous systems. Under normal physiological conditions, neurotensin is involved in the regulation of pain, body temperature, physical activity, appetite as well as learning and memory. In
V E Eysselein
Klinische Wochenschrift, 62(11), 523-530 (1984-06-01)
Neurotensin is a tridecapeptide originally isolated and characterized from bovine hypothalamus and later, in identical form, from bovine and human intestine. In the rat about 85% of immunoreactive neurotensin is found in the gut and about 10% in the brain.
Neurotensin Receptor Agents
Wendy Marsh
xPharm: The Comprehensive Pharmacology Reference, 1-3 (1007)

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