05-1938
Anti-G3BP1 Antibody, clone 14E5-G9
clone 14E5-G9, from mouse
别名:
ATP-dependent DNA helicase VIII, GAP SH3 domain-binding protein 1, GAP binding protein, GTPase activating protein (SH3 domain) binding protein 1, Ras-GTPase-activating protein SH3-domain-binding protein, RasGAP-associated endoribonuclease G3BP
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所有图片(1)
About This Item
UNSPSC代码:
12352203
eCl@ss:
32160702
生物来源
mouse
质量水平
抗体产品类型
primary antibodies
克隆
14E5-G9, monoclonal
种属反应性
human
技术
immunocytochemistry: suitable
western blot: suitable
同位素/亚型
IgG1κ
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... G3BP1(10146)
一般描述
G3BP1 (Ras-GTPase activating protein SH3-domain binding protein 1) directly associates with SH3 domains of GTPase activating proteins (GAPs). It was first discovered by its binding to RasGAP. G3BPs have been shown to be involved in a number of mitogenic signaling pathways. G3BP1 is also known to be over expressed in many human cancers (Kim, 2007) and its expression appears to be inversely correlated with PTEN expression (Kim, 2007). Interestingly, G3BP1, along with G3BP2, has been shown to bind to the C-terminus of p53, playing a crucial role in its activity (Kim, 2007). Furthermore, the G3BPs have two traditional RNA binding motifs.
特异性
This antibody recognizes G3BP1.
免疫原
GST-tagged recombinant protein corresponding to human G3BP1.
应用
Anti-G3BP1 Antibody, clone 14E5-G9 is an antibody against G3BP1 for use in WB & IC.
Research Sub Category
RNA Metabolism & Binding Proteins
G-proteins
RNA Metabolism & Binding Proteins
G-proteins
质量
Evaluated by Western Blot in K562 cell lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected G3BP1 on K562 cell lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected G3BP1 on K562 cell lysate.
目标描述
52 kDa
外形
Format: Purified
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Yu Sun et al.
Nature communications, 11(1), 3354-3354 (2020-07-06)
Expansion of an intronic (GGGGCC)n repeat region within the C9orf72 gene is a main cause of familial amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD). A hallmark of c9ALS/FTD is the accumulation of misprocessed RNAs, which are often targets of cellular
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