推荐产品
生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
2A7, monoclonal
种属反应性
human, mouse, rat, avian
制造商/商品名称
Upstate®
技术
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
同位素/亚型
IgG1
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... PTK2(5747)
特异性
Recognizes FAK.
免疫原
Mixture of affinity-purified tyrosine phosphoproteins from chick embryo fibroblasts expressing p125FAK.
应用
Anti-FAK Antibody, clone 2A7 detects level of FAK & has been published & validated for use in IC & IP.
Not recommended in Western Blot
Research Category
Signaling
Signaling
Research Sub Category
Cytoskeletal Signaling
Cytoskeletal Signaling
质量
routinely evaluated by immunoprecipitation of FAK from a mouse 3T3/A31 RIPA cell lysate, subsequently immunobloted with Anti-FAK (Catalog #06-543)
目标描述
125 kDa
联系
Replaces: 04-591
外形
Protein G Purified
Format: Purified
Protein G Purified immunoglobulin in Protein G Purified immunoglobulin in Purified immunoglobulin in 10mM PBS, pH 7.4 containing no preservatives.
储存及稳定性
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
分析说明
Control
Expressed in most tissue, 3T3/A31 cell lysate
Expressed in most tissue, 3T3/A31 cell lysate
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Tyrosine phosphorylation of paxillin and focal adhesion kinase during insulin-like growth factor-I-stimulated lamellipodial advance.
Leventhal, P S, et al.
The Journal of Biological Chemistry, 272, 5214-5218 (1997)
F Burgaya et al.
The Journal of biological chemistry, 272(45), 28720-28725 (1997-11-14)
pp125 focal adhesion kinase (FAK), a cytoplasmic tyrosine kinase transducing signals initiated by integrin engagement and G protein-coupled receptors, is highly expressed in brain. FAK from brain had a higher molecular weight and an increased autophosphorylation activity, than from other
Ambivalent role of pFAK-Y397 in serous ovarian cancer--a study of the OVCAD consortium.
Aust, S; Auer, K; Bachmayr-Heyda, A; Denkert, C; Sehouli, J; Braicu, I; Mahner et al.
Molecular Cancer null
S S Kantak et al.
The Journal of biological chemistry, 273(27), 16953-16961 (1998-06-27)
Integrin-basement membrane interactions provide essential signals that promote survival and growth of epithelial cells, whereas loss of such adhesions triggers programmed cell death. We found that HSC-3 human squamous carcinoma cells survived and grew readily as monolayers, but when they
Niki Tzenaki et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(12), 4840-4852 (2015-08-08)
The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) tumor suppressor protein is regulated by various mechanisms that are not fully understood. This includes regulation by Tyr phosphorylation by a mechanism that remains elusive. Here, we show that focal
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