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05-1113

Sigma-Aldrich

Anti-Harmartin (TSC1) Antibody

ascites fluid, from mouse

别名:

Tuberous sclerosis 1 protein, tuberous sclerosis 1, tumor suppressor

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About This Item

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

mouse

质量水平

抗体形式

ascites fluid

抗体产品类型

primary antibodies

克隆

monoclonal

种属反应性

human, rat

技术

immunohistochemistry: suitable (paraffin)
western blot: suitable

同位素/亚型

IgG1

UniProt登记号

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

human ... TSC1(7248)

一般描述

Harmartin is the gene product of tuberous sclerosis-1 (TSC1). It is thought to have a tumor suppression function and also augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination.

特异性

This antibody recognizes Harmartin

免疫原

Recombinant protein from human Harmartin

应用

Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Harmartin in human skin tissue, melanocytes.
Research Category
Signaling
Research Sub Category
PI3K, Akt, & mTOR Signaling
This Anti-Harmartin (TSC1) Antibody is validated for use in WB, IH(P) for the detection of Harmartin (TSC1).

质量

Evaluated by Western Blot in NIH/3T3 cell lysate.
Western Blot Analysis: 1:500 dilution of this antibody detected Harmartin in 10 µg of NIH/3T3 cell lysate.

目标描述

Approx. 160 kDa

联系

Replaces: 04-426

外形

Unpurified ascites fluid
Ascites fluid. Liquid. Contains no preservative.

储存及稳定性

Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.

分析说明

Control
NIH/3T3 cell lysate

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Xiaoping Wu et al.
Cell reports, 40(3), 111085-111085 (2022-07-21)
Tuberous sclerosis complex (TSC) is a developmental disorder associated with epilepsy, autism, and cognitive impairment. Despite inactivating mutations in the TSC1 or TSC2 genes and hyperactive mechanistic target of rapamycin (mTOR) signaling, the mechanisms underlying TSC-associated neurological symptoms remain incompletely

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