04-824
抗雌激素受体β抗体，克隆68-4，兔单克隆
culture supernatant, clone 68-4, from rabbit
别名:
Estradiol receptor, Nuclear receptor subfamily, estrogen receptor 1, estrogen receptor alpha
产品名称
抗雌激素受体β抗体，克隆68-4，兔单克隆, culture supernatant, clone 68-4, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
68-4, monoclonal
species reactivity
mouse, rat, human
technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ESR2(2100)
mouse ... Esr2(13983)
rat ... Esr2(25149)
Analysis Note
已通过蛋白质印迹对MCF-7细胞的RIPA裂解液进行了评估。
蛋白质印迹分析：
该抗体的1:500-1:2,000稀释液在MCF-7细胞的RIPA裂解液中检测到雌激素受体β。
蛋白质印迹分析：
该抗体的1:500-1:2,000稀释液在MCF-7细胞的RIPA裂解液中检测到雌激素受体β。
Application
使用经验证可用于WB & IP的抗雌激素受体β抗体（克隆68-4）检测雌激素受体β。
免疫沉淀：
10 μg先前批次已对500 μg MCF7 RIPA裂解液中的雌激素受体β进行了免疫沉淀。
10 μg先前批次已对500 μg MCF7 RIPA裂解液中的雌激素受体β进行了免疫沉淀。
Biochem/physiol Actions
根据序列同源性，预测与小鼠和大鼠发生交叉反应。
长形式的雌激素受体 β，不检测雌激素受体α。
General description
雌激素受体（ER）是配体激活的转录因子的类固醇/甲状腺激素受体超家族的成员。包括ERα 和ERβ 在内的雌激素受体含有 DNA 结合域和配体结合域，并且在调节生殖组织的正常功能中起关键作用。它们位于细胞核中，尽管一些雌激素受体与细胞表面膜结合，并且当细胞接触雌激素，它会被快速激活。研究表明，ERα 和ERβ 可被各种配体差异激活。受体-配体相互作用触发一系列事件，包括与热激蛋白解离、受体二聚化、磷酸化以及激素激活受体与靶基因中特定调控元件的结合。有证据表明，尽管ERα 和ERβ 具有许多功能特征，但它们可能受不同机制的调节。
59kDa
Immunogen
KLH结合的合成肽，对应于大鼠和小鼠雌激素受体β的氨基酸63-82和人雌激素受体β的氨基酸55-74。
表位：a.a.55-74(H) 或63-82 (R, M)
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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