推荐产品
生物来源
mouse
质量水平
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
2121, monoclonal
种属反应性
human
包装
antibody small pack of 25 μL
制造商/商品名称
Upstate®
技术
western blot: suitable
同位素/亚型
IgG1
NCBI登记号
UniProt登记号
运输
dry ice
基因信息
human ... SREBF1(6720)
特异性
可与SREBP的碱性螺旋-环-螺旋亮氨酸拉链（bHLH-ZIP）发生反应。
免疫原
包含氨基酸301-407的重组His标签人SREBP-1a蛋白。
应用
抗SREBP1抗体，克隆2121，是一种小鼠单克隆抗体，可用于检测SREBP1（也被称为固醇调节元件结合转录因子1 &），其已在WB中进行验证。
质量
已通过免疫印迹进行常规评估。
目标描述
126kda
外形
100 μL（1 mg/mL）蛋白A纯化的小鼠单克隆IgG1，溶于含0.1％叠氮化钠的PBS中。
形式：纯化
储存及稳定性
自收到之日起在-20°C可稳定保存2年。 第一次融化后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。 分装到微量离心管中，并储存于 -20°C。 避免反复冻融循环，以免损坏 IgG 和影响产品性能。 注意： 冷藏室温度变化至低于-20°C时可能导致-含甘油的溶液在储存过程中冻结。
其他说明
请参考特定批次的数据表。
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Tanel Punga et al.
The Journal of biological chemistry, 281(35), 25278-25286 (2006-07-11)
Members of the sterol regulatory element-binding protein (SREBP) family of transcription factors control cholesterol and lipid metabolism and play critical roles during adipocyte differentiation. The transcription factor SREBP1 is degraded by the ubiquitin-proteasome system following phosphorylation of Thr426 and Ser430
X Wang et al.
The Journal of biological chemistry, 268(19), 14497-14504 (1993-07-05)
This paper describes the purification and characterization of a sterol regulatory element binding protein (SREBP) that recognizes the SRE-1 sequence in the 5' flanking region of the gene for the low density lipoprotein (LDL) receptor. The protein was purified more
Shreetama Bandyopadhayaya et al.
Journal of biochemical and molecular toxicology, 35(4), e22693-e22693 (2021-01-05)
N-acyl dopamines (NADAs) are bioactive lipids of the endovanilloid family with known cytotoxicity for the cancer cells; however, the available data on the participation of the endovanilloids in epithelial-mesenchymal transition (EMT) and cancer stemness are controversial. This study unveils the
Amy K Walker et al.
Genes & development, 24(13), 1403-1417 (2010-07-03)
The sterol regulatory element-binding protein (SREBP) transcription factor family is a critical regulator of lipid and sterol homeostasis in eukaryotes. In mammals, SREBPs are highly active in the fed state to promote the expression of lipogenic and cholesterogenic genes and
Ankit Sharma et al.
PloS one, 14(1), e0209435-e0209435 (2019-01-10)
Metformin, a widely prescribed anti-diabetic drug, shows anticancer activity in various cancer types. Few studies documented that there was a decreased level of LDL and total cholesterol in blood serum of metformin users. Based on these views, this study aimed
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