推荐产品
生物来源
mouse
质量水平
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
10C3, monoclonal
种属反应性
human
制造商/商品名称
Upstate®
技术
activity assay: suitable
western blot: suitable
同位素/亚型
IgG1
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
phosphorylation (pTyr1150/pTyr1151)
基因信息
human ... INSR(3643)
特异性
可识别胰岛素受体中酪氨酸1150/1151上的磷酸化结构域。
免疫原
KLH偶联的合成肽，对应于磷酸化胰岛素受体上酪氨酸1150/1151周围的氨基酸。
应用
使用经验证可用于EA & WB的该抗磷酸化胰岛素受体（Tyr 1150/1151）抗体（克隆10C3）检测磷酸化胰岛素受体（Tyr 1150/1151）。
质量
已通过免疫印迹进行常规评估。
目标描述
97kda
外形
形式：纯化
溶于含0.09%叠氮化钠、PEG、蔗糖和50%甘油的1 mL PBS。
分析说明
对照
包括过钒酸盐处理的HEK293 裂解液作为阳性对照
包括过钒酸盐处理的HEK293 裂解液作为阳性对照
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Natalie N Rizk et al.
Fertility and sterility, 86(4 Suppl), 1217-1222 (2006-09-12)
To determine whether the insulin receptor (IR), insulin-like growth factor-I receptor (IGF-IR), and IGF-I are expressed differentially in fibroblasts isolated from normal peritoneal and adhesion tissue before and after 24-hour treatment with increasing glucose concentrations. Prospective experimental study. University medical
Qiu-yan Wang et al.
The FEBS journal, 274(2), 526-538 (2007-01-19)
Two H7721 human hepatocarcinoma cell lines showing moderate and high expression of alpha1,3-fucosyltransferase (FucT)-VII cDNA were established and designated FucTVII-M and FucTVII-H, respectively. In alpha1,3-FucT-VII-transfected cells, expression of insulin receptor (InR) alpha- and beta subunits and epidermal growth factor receptor
Atsumi Tsuji-Hosokawa et al.
Pediatric diabetes, 18(8), 917-924 (2017-02-10)
Defects of the insulin receptor gene ( INSR ) cause wide spectra of congenital insulin resistance. Monoallelic defects result in milder insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN, type A). Whereas, leprechaunism (Donahue syndrome), the most severe condition with lethality
Adrián Martín-Segura et al.
Aging cell, 18(3), e12932-e12932 (2019-03-19)
In the brain, insulin plays an important role in cognitive processes. During aging, these faculties decline, as does insulin signaling. The mechanism behind this last phenomenon is unclear. In recent studies, we reported that the mild and gradual loss of
Rita Slaaby et al.
The Journal of biological chemistry, 281(36), 25869-25874 (2006-07-13)
Insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) are both from the same subgroup of receptor tyrosine kinases that exist as covalently bound receptor dimers at the cell surface. For both IR and IGF-IR, the most described forms
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