04-262
抗泛素化蛋白抗体，克隆FK1
clone FK1, Upstate®, from mouse
别名:
抗泛素抗体
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
FK1, monoclonal
Technique(s):
immunohistochemistry: suitable
western blot: suitable
western blot: suitable
Application:
immunohistochemistry
western blot
western blot
Citations:
24
产品名称
抗泛素化蛋白抗体，克隆FK1, clone FK1, Upstate®, from mouse
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
FK1, monoclonal
species reactivity (predicted by homology)
all
manufacturer/tradename
Upstate®
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype
IgM
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Application
抗泛素化蛋白抗体，克隆FK1是针对泛素化蛋白的抗体，用于WB，IH。
研究子类别
泛素 & 泛素代谢
泛素 & 泛素代谢
研究类别
蛋白运输
蛋白运输
Biochem/physiol Actions
仅识别多泛素化蛋白，不识别单泛素化蛋白或游离泛素。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
泛素是由76个氨基酸残基组成的多肽，是所有真核细胞中高度保守且分布广泛的蛋白质。已经提出泛素在各种生物学过程中起重要作用，例如细胞周期的调节，DNA复制，DNA修复，应激反应，细胞凋亡，信号转导以及核糖体，核小体，过氧化物酶体和肌原纤维的生物发生。在这些过程中，泛素既充当蛋白质降解的信号，又充当促进细胞器形成的分子伴侣。
Immunogen
多泛素化溶菌酶。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
100 µL浓度为1mg/mL的纯化免疫球蛋白，溶于含0.1%叠氮化钠的PBS中。用磷酸盐缓冲盐水（pH 7.2-7.4）稀释至工作浓度。
形式：纯化
Preparation Note
自运输之日起，在2-8°C下可稳定保存1年，最长可保存12个月。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Kaisa Haglund et al.
Nature cell biology, 5(5), 461-466 (2003-04-30)
Many cellular proteins are post-translationally modified by the addition of a single ubiquitin or a polyubiquitin chain. Among these are receptor tyrosine kinases (RTKs), which undergo ligand-dependent ubiquitination. The ubiquitination of RTKs has become recognized as an important signal for
Chris McKinnon et al.
Acta neuropathologica, 131(3), 411-425 (2015-12-10)
Prion diseases are a group of fatal neurodegenerative disorders characterised by the accumulation of misfolded prion protein (PrP(Sc)) in the brain. The critical relationship between aberrant protein misfolding and neurotoxicity currently remains unclear. The accumulation of aggregation-prone proteins has been
Javier H Jara et al.
Cerebral cortex (New York, N.Y. : 1991), 25(11), 4259-4272 (2015-01-18)
Corticospinal motor neurons (CSMN) receive, integrate, and relay cerebral cortex's input toward spinal targets to initiate and modulate voluntary movement. CSMN degeneration is central for numerous motor neuron disorders and neurodegenerative diseases. Previously, 5 patients with mutations in the ubiquitin
Miao Li et al.
Methods in molecular biology (Clifton, N.J.), 1436, 85-94 (2016-06-02)
Histone deacetylase 6 (HDAC6) is a member of class IIb HDAC family. HDAC6 exists predominantly in the cytoplasm and deacetylates mainly non-histone proteins in the cytoplasm. Via its deacetylase and ubiquitin binding domains, HDAC6 regulates microtubules, cytoskeleton, intracellular trafficking, and
Kunikazu Tanji et al.
Acta neuropathologica communications, 2, 50-50 (2014-06-03)
Extensive research on p62 has established its role in oxidative stress, protein degradation and in several diseases such as Paget's disease of the bone, frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Importantly, previous studies showed that p62 binds directly to
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