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Merck
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主要文件

04-262

Sigma-Aldrich

抗泛素化蛋白抗体,克隆FK1

clone FK1, Upstate®, from mouse

别名:

Anti-Ubiquitin Antibody

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About This Item

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

mouse

质量水平

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

FK1, monoclonal

种属反应性(根据同源性预测)

all

制造商/商品名称

Upstate®

技术

immunohistochemistry: suitable
western blot: suitable

同位素/亚型

IgM

运输

wet ice

靶向翻译后修饰

unmodified

一般描述

泛素是由76个氨基酸残基组成的多肽,是所有真核细胞中高度保守且分布广泛的蛋白质。已经提出泛素在各种生物学过程中起重要作用,例如细胞周期的调节,DNA复制,DNA修复,应激反应,细胞凋亡,信号转导以及核糖体,核小体,过氧化物酶体和肌原纤维的生物发生。在这些过程中,泛素既充当蛋白质降解的信号,又充当促进细胞器形成的分子伴侣。

特异性

仅识别多泛素化蛋白,不识别单泛素化蛋白或游离泛素。

免疫原

多泛素化溶菌酶。

应用

抗泛素化蛋白抗体,克隆FK1是针对泛素化蛋白的抗体,用于WB,IH。
研究子类别
泛素 & 泛素代谢
研究类别
蛋白运输

外形

100 µL浓度为1mg/mL的纯化免疫球蛋白,溶于含0.1%叠氮化钠的PBS中。用磷酸盐缓冲盐水(pH 7.2-7.4)稀释至工作浓度。
形式:纯化

储存及稳定性

自运输之日起,在2-8°C下可稳定保存1年,最长可保存12个月。

其他说明

浓度:请参考批次特异性浓缩物的分析证书。

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

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Chris McKinnon et al.
Acta neuropathologica, 131(3), 411-425 (2015-12-10)
Prion diseases are a group of fatal neurodegenerative disorders characterised by the accumulation of misfolded prion protein (PrP(Sc)) in the brain. The critical relationship between aberrant protein misfolding and neurotoxicity currently remains unclear. The accumulation of aggregation-prone proteins has been
Haopeng Wang et al.
The EMBO journal, 29(7), 1285-1298 (2010-02-13)
Expression of the T-cell receptor (TCR):CD3 complex is tightly regulated during T-cell development. The mechanism and physiological role of this regulation are unclear. Here, we show that the TCR:CD3 complex is constitutively ubiquitylated in immature double positive (DP) thymocytes, but
Hugues Lelouard et al.
Nature, 417(6885), 177-182 (2002-05-10)
Dendritic cells (DCs) are antigen-presenting cells with the unique capacity to initiate primary immune responses. Dendritic cells have a remarkable pattern of differentiation (maturation) that exhibits highly specific mechanisms to control antigen presentation restricted by major histocompatibility complex (MHC). MHC
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Methods in molecular biology (Clifton, N.J.), 1436, 85-94 (2016-06-02)
Histone deacetylase 6 (HDAC6) is a member of class IIb HDAC family. HDAC6 exists predominantly in the cytoplasm and deacetylates mainly non-histone proteins in the cytoplasm. Via its deacetylase and ubiquitin binding domains, HDAC6 regulates microtubules, cytoskeleton, intracellular trafficking, and
Javier H Jara et al.
Cerebral cortex (New York, N.Y. : 1991), 25(11), 4259-4272 (2015-01-18)
Corticospinal motor neurons (CSMN) receive, integrate, and relay cerebral cortex's input toward spinal targets to initiate and modulate voluntary movement. CSMN degeneration is central for numerous motor neuron disorders and neurodegenerative diseases. Previously, 5 patients with mutations in the ubiquitin

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