所有图片(1)
72 kDa ICln-binding protein, HMT1 hnRNP methyltransferase-like 5, Jak-binding protein 1, SKB1 homolog, SKB1 homolog (S. pombe), Shk1 kinase-binding protein 1 homolog, protein arginine methyltransferase 5, skb1 (S. pombe) homolog
推荐产品
生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
23C7, monoclonal
种属反应性
human
技术
western blot: suitable
同位素/亚型
IgG1κ
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... PRMT5(10419)
一般描述
Arginine methylation of proteins is mediated by the Protein-Arginine Methyl Transferase (PRMT) family of enzymes, which are important in signal transduction, transcription, RNA transport, and splicing. PRMTs are divided into two types defined by their activity. Type I PRMTs (including PRMT 1, 3, 4, and 6) are characterized by the formation of asymmetric dimethylated arginine residues. Type II PRMTs, which include only PRMT5, are defined by the formation of symmetric dimethylated arginine residues. Substrates for PRMT5 include myelin basic protein (MBP) and the spliceosomal D1 and D3 proteins. PRMT5 (also known as Skb1Hs/JBP1) exists as homooligomeric complexes, which includes a dimer and tetramer. Homooligomerization of PRMT5 has an important role in its ability to methylate the MBP protein.
特异性
This antibody recognizes PRMT5.
免疫原
Recombinant protein corresponding to human PRMT5.
应用
Research Sub Category
Histone Modifying Proteins
RNA Metabolism & Binding Proteins
Histone Modifying Proteins
RNA Metabolism & Binding Proteins
Use Anti-PRMT5 Antibody, clone 23C7 (mouse monoclonal antibody) validated in WB to detect PRMT5 also known as 72 kDa ICCln-binding protein, HMT1 hnRNP methyltransferase-like 5, Jak-binding protein 1, SKB1 homolog.
质量
Evaluated by Western Blot in K562 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected PRMT5 on 10 µg of K562 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected PRMT5 on 10 µg of K562 cell lysate.
目标描述
~72 kDa observed
联系
Replaces: MABE551
外形
Format: Purified
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
WGK
WGK 1
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