Histone H2B human recombinant

Histone H2B is one of four core histones that form an octameric structure required for the packaging of DNA into nucleosomes, the most basic level of chromatin arrangement. Histones undergo a number of post-translational modifications (PTM) at their N- and C-terminal tails which can influence chromatin structure and stability and consequently, transcription, and DNA replication and repair. The most widely studied of these modifications are methylation, phosphorylation, and acetylation which may produce different effects on gene regulation depending on the number and pattern of modifications. Histone H2B undergoes acetylation at lysines 5, 15, and 20. It is also phosphorylated in apoptotic cells during DNA fragmentation, possibly in a caspase-dependent manner.

Human recombinant H2B expressed in E. Coli

~17 kDa

Chromatin assembly, Western blot (control), Kinase Assay

Liquid in Dulbecco′s PBS. Frozen solution.

Stable for 12 months at -80°C from date of receipt. Avoid multiple freeze/thaw cycles.

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